amyloid angiopathy


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am·y·loid an·gi·op·a·thy

deposition of acellular hyaline material in small arteries and arterioles of the leptomeninges and cerebral cortex in the elderly with resulting predilection for recurrent lobar intraparenchymal hematomas.

amyloid angiopathy

An abnormality of cerebral blood vessels in which amyloid is deposited in the walls of small arteries and arterioles. It may occur in those with chronic infectious and inflammatory disorders or B-cell lymphoma and is a common contributor to intracerebral hemorrhage or Alzheimer's disease in the elderly.
See also: angiopathy
References in periodicals archive ?
The growing clinical spectrum of cerebral amyloid angiopathy. Curr Opin Neurol.
Trauma related ICH 45 cases (50%) Hypertensive ICH 18 cases (20%) Aneurysm & AVM related ICH 19 cases (21.1%) Others like Amyloid angiopathy, 8 cases (8.9%) haemorrhagic metastasis& haemorrhagic Transformation of ischemic infarct Total Cases 90 cases Among 15 cases of haemorrhage secondary to aneurysms, the aneurysm is identified on MR TOF Angiogram sequence in 12 cases which is not evident on plain CT scan, in rest of the 3 cases the aneurysm is identified on further investigation with CT Angiogram.
Functional magnetic resonance imaging detection of vascular reactivity in cerebral amyloid angiopathy. Ann Neurol 2012;72:76-81.
EXAMPLE 5, SAMPLE AUTOPSY SICNOUT: * Alzheimer disease neuropathologic changes, "high", A3B3C2: *** Thal phase for amyloid plaques: 5 (A3) *** Braak and Braak neurofibrillary stage: VI (B3) *** CERAD neuritic plaque score: Moderate (C2) *** Cerebral amyloid angiopathy, diffuse *** TDP-43 proteinopathy, with: ** Hippocampal sclerosis, bilateral, severe ** Frequent pathologic inclusions in hippocampus proper, dentate gyrus, limbic regions, and basal forebrain * No Lewy body pathology is identified Comment: "High" AD neuropathologic change is identified, which per the 2012 NIA/AA guidelines is considered adequate explanation for clinical diagnosis of dementia in the appropriate context (Moline et al., 2012).
Grube et al., "Lack of Pglycoprotein results in impairment of removal of betaamyloid and increased intraparenchymal cerebral amyloid angiopathy after active immunization in a transgenic mouse model of Alzheimer's disease," Current Pharmaceutical Design, vol.
Ihara, "New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy," Frontiers in Aging Neuroscience, vol.
Cerebral Amyloid Angiopathy. In: UpToDate, Kasner SE (Ed), UpToDate, Waltham, MA.
Cerebral amyloid angiopathy is now considered an important cause of lobar hemorrhage, multifocal microhemorrhagic in the elderly.
Pritchard et al., "A 3'-UTR polymorphism in the oxidized LDL receptor 1 gene increases A/540 load as cerebral amyloid angiopathy in Alzheimer's disease," Acta Neuropathologica, vol.
The neuropathology of the two most common diseases associated with cerebral microhemorrhages on MR imaging, cerebral amyloid angiopathy, and chronic systemic hypertension, are typified by a progressive small-vessel vasculopathy.
Wednesday, July 7, at Buell Funeral Chapel in Springfield for Katherine Rae Doerksen of Eugene, who died June 30 of cerebral amyloid angiopathy. She was 67.