Mammalian mitochondrial Top IIb has been found to be inhibited by the anticancer drugs amsacrine
and teniposide  and it is possible that various known nuclear Top II poisons, ranging from the fungal toxin alternariol  and chemotherapeutics  to dietary components such as bioflavonoids from fruit and vegetables , may also inhibit the truncated or full-length type II topoisomerases in mitochondria.
as a topoisomerase II poison: importance of drug-DNA interactions," Biochemistry, vol.
and sulfonylhydrazines, sulphonamide derivatives, are antineoplastic agents that are frequently used in cancer chemotherapy [5, 6].
The latter tolerates 6-400-fold higher concentration of various antineoplastic agents compared to humans (e.g., Amethopterin, Nitromin, Cytoxan, ThioTEPA, Myleran, Pactamycin, Carboplatin, Amsacrine
, Thalicarpine, Chlorozotocin, and Fludarabine) .
'e inspection report stated: "A critical deciency was cited regarding potential product cross contamination, it was found that the company were manufacturing a potent cytotoxic (Amsacrine
) product in the non-potent suite.
Topoisomerase II is one of the well-known targets for antitumor agents like doxorubicin, etoposide, ellipticine, and amsacrine
Antimetabolites, tubulin-binding agents, platinum drugs, amsacrine
, L-asparaginase, interferons, steroids and other miscellaneous antitumour agents," Cancer Chemotherapy and Phar macology, vol.
To date, it is known that, on simultaneous addition or right after the main drug, CAF diminishes the toxicity of the antitumour antibiotics doxorubicin [30, 31, 33, 37-39], mitoxantrone [32, 33, 37, 39], ellipticine [33, 38], amsacrine
, camptothecins [38, 40], and phenothiazine drugs  as well as the aromatic mutagen ethidium bromide and aromatic neurotoxin tetrahydropyridine .
remission induction courses with cytarabine, daunorubicin, and etoposide [ADE] given for 10, 3, and 5 d, respectively, for the 1 st course, and 8, 3, and 5 d, respectively, for the 2nd course, and 2 consolidation courses consisting of amsacrine
, cytarabine, etoposide [MACE], and MidAC [mitoxantrone, cytarabine] and triple intrathecal chemotherapy given once after each chemotherapy courses (14).
The chemotherapeutic agents nocodazole and amsacrine
cause meiotic delay and non-disjunction in spermatocytes of mice.
One month later the first consolidation chemotherapy (cytarabine + amsacrine
) was done and 6 days afterwards the patient presented diarrhoea without abdominal pain or fever.