amsacrine


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amsacrine

A topoisomerase inhibitor with antineoplastic activity; it can also intercalate into the DNA of tumour cells, altering major and minor grooves therein, thereby inhibiting DNA replication and transcription by reducing association between the altered DNA and DNA polymerase, RNA polymerase and transcription factors.

Indications
Acute lymphoblastic leukaemia, lymphoma.

Adverse effects
Bone marrow suppression.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

amsacrine

A cytotoxic drug used to treat acute myeloid leukaemia. A brand name is Amsidine.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Mammalian mitochondrial Top IIb has been found to be inhibited by the anticancer drugs amsacrine and teniposide [288] and it is possible that various known nuclear Top II poisons, ranging from the fungal toxin alternariol [289] and chemotherapeutics [290] to dietary components such as bioflavonoids from fruit and vegetables [291], may also inhibit the truncated or full-length type II topoisomerases in mitochondria.
Amsacrine and sulfonylhydrazines, sulphonamide derivatives, are antineoplastic agents that are frequently used in cancer chemotherapy [5, 6].
The latter tolerates 6-400-fold higher concentration of various antineoplastic agents compared to humans (e.g., Amethopterin, Nitromin, Cytoxan, ThioTEPA, Myleran, Pactamycin, Carboplatin, Amsacrine, Thalicarpine, Chlorozotocin, and Fludarabine) [15].
'e inspection report stated: "A critical deciency was cited regarding potential product cross contamination, it was found that the company were manufacturing a potent cytotoxic (Amsacrine) product in the non-potent suite.
Topoisomerase II is one of the well-known targets for antitumor agents like doxorubicin, etoposide, ellipticine, and amsacrine [12].
Antimetabolites, tubulin-binding agents, platinum drugs, amsacrine, L-asparaginase, interferons, steroids and other miscellaneous antitumour agents," Cancer Chemotherapy and Phar macology, vol.
To date, it is known that, on simultaneous addition or right after the main drug, CAF diminishes the toxicity of the antitumour antibiotics doxorubicin [30, 31, 33, 37-39], mitoxantrone [32, 33, 37, 39], ellipticine [33, 38], amsacrine [34], camptothecins [38, 40], and phenothiazine drugs [41] as well as the aromatic mutagen ethidium bromide [42]and aromatic neurotoxin tetrahydropyridine [43].
remission induction courses with cytarabine, daunorubicin, and etoposide [ADE] given for 10, 3, and 5 d, respectively, for the 1 st course, and 8, 3, and 5 d, respectively, for the 2nd course, and 2 consolidation courses consisting of amsacrine, cytarabine, etoposide [MACE], and MidAC [mitoxantrone, cytarabine] and triple intrathecal chemotherapy given once after each chemotherapy courses (14).
The chemotherapeutic agents nocodazole and amsacrine cause meiotic delay and non-disjunction in spermatocytes of mice.
One month later the first consolidation chemotherapy (cytarabine + amsacrine) was done and 6 days afterwards the patient presented diarrhoea without abdominal pain or fever.