The importance of hydroxyethylamine moiety has been studied extensively as a backbone replacement of amide bonds in the P1/P1' position of aspartyl protease inhibitors like Amprenavir
, Nelfinavir , and Saquinavir .
Regimens containing saquinavir (SQV) and amprenavir
(APV) were the only ones that did not undergo any modification (Figure 2).
En el caso de los antirretrovirales In vitro se ha mostrado que el amprenavir
es un potente inhibidor de la proteina blanco reduciendo la actividad proteolitica de C.
The company offers protease inhibitors such as ritonavir, darunavir, saquinavir, amprenavir
, lopinavir, atazanavir, indinavir and tipranavir.
Dailly et al., "A liquid chromatography-tandem mass spectrometry assay for quantification of nevirapine, indinavir, atazanavir, amprenavir
, saquinavir, ritonavir, lopinavir, efavirenz, tipranavir, darunavir and maraviroc in the plasma of patients infected with HIV," Journal of Chromatography B, vol.
Xuereb et al., "Simultaneous determination of the antiretroviral agents: amprenavir
, lopinavir, ritonavir, saquinavir and efavirenz in human peripheral blood mononuclear cells by high-performance liquid chromatography-mass spectrometry," Journal of Chromatography B, vol.
Oxidative metabolism of amprenavir
in the human liver.
The protease inhibitors (PIs) ritonavir, nelfinavir reduce while atazanavir, amprenavir
and indinavir increase contraceptive steroid levels.
Treatment with anti-retroviral drugs had been prescribed for 119 (70.4%) infected patients, out of which 53 (44.5%) employed protease inhibitors: one of the infected patients was being treated with Tenofovir; two with Indinavir; 14 with Atazanavir, 13 with Nelfinavir and 23 with Ritonavir associated with another protease inhibitors (Lopinavir, Atazanavir, Amprenavir
and nelfinavir, develop specific primary mutations first without conferring cross-resistance to other PIs.