amphotericin B


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Related to amphotericin B: liposomal amphotericin B

amphotericin B

 [am″fo-ter´ĭ-sin]
an antifungal agent and antibiotic used to treat deep-seated fungal infections, especially histoplasmosis, and also to treat cutaneous and mucocutaneous candidiasis. It may be applied topically or administered intravenously or by intracavitary instillation. Anorexia, chills, fever, and headache may occur as side effects. Renal damage with evidence of renal tubular acidosis occurs, but usually clears when the drug is discontinued.

am·pho·ter·i·cin

, amphotericin B (am'fō-tār'i-sin),
An amphoteric polyene antibiotic prepared from Streptomyces nodosus and available as the sodium deoxycholate complex; also a nephrotoxic antifungal agent used extensively in the treatment of systemic mycoses.

amphotericin B

(ăm′fə-tĕr′ĭ-sĭn)
n.
An antibiotic derived from strains of the actinomycete Streptomyces nodosus and used to treat systemic fungal infections.

amphotericin B

Infectious disease A heptaene macrolide antibiotic produced by the bacteria, Streptomyces nodosus, administered IV Effective against Blastomycosis dermatitidis, Candida, Coccidioides immitis, Cryptococcus neoformans, H capsulatum, Paracoccidioides braziliensis, Torulopsis glabrata Adverse effects Severe–fever, azotemia, nephrotoxicity, chills, headache, anorexia, N&V, diarrhea, kidney damage, BM suppression Lab Hypochromic normocytic anemia, neutropenia See Amphotec, Liposome.

Amphotericin B (Fengizone)

An antifungal medication, prescribed for topical or systemic use in treating fungal infections.

antifungal agent 

Any substance which destroys or prevents the growth of fungi. It is one of the antibiotic groups. There are several classes of antifungal drugs: Polyenes, which cause an increase in fungal cell wall permeability leading to its death. Examples: amphotericin B, natamycin, nystatin. Azoles, which act either by inhibiting the synthesis of ergosterol, a component of fungal cell wall or by causing direct wall damage. Examples: clotrimazole, econazole, fluconazole, itraconazole, ketoconazole, miconazole. Pyrimidines, which interfere with the normal function of fungal cells. Example: flucytosine. Syn antimycotic agent.

am·pho·ter·i·cin

, amphotericin B (amfō-teri-sin)
An amphoteric antibiotic and nephrotoxic antifungal agent used extensively to treat systemic mycoses.
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References in periodicals archive ?
(2) Adverse Effects of Amphotericin B. AmB interacts with cholesterol in human cell membranes accounting for the adverse effects and toxicities.
Einstein, "Amphotericin B and coccidioidomycosis," Annals of the New York Academy of Sciences, vol.
Table: Effects of coadministration of amphotericin B and cyclosporine on renal functions of rabbit; Group A (Control) vs Group E (Amphotericin B + cyclosporine): Serum analysis:
The antifungal drugs currently available for the treatment of invasive mycoses can be divided into four different classes on the basis of their mechanisms of action: (1) Alteration of membrane function (amphotericin B); (2) inhibition of DNA or RNA synthesis (flucytosine); (3) inhibition of ergosterol biosynthesis (azoles [fluconazole, itraconazole, and the newer agents voriconazole, posaconazole, and ravuconazole]); and (4) inhibition of glucan synthesis (echinocandins [caspofungin, micafungin, and anidulafungin]).
guilliermondii showed sensitivity to Voriconazole, Caspofungin and Micafungin were 60%; Amphotericin B, Flucytosine and Fluconazole were 80% each.
varied from 0.343 to 1.624 mg [L.sup.-1] for amphotericin B, from 0.046 to 15.021 mg [L.sup.-1] for itraconazole, and from 0.659 to 82.346 mg [L.sup.-1] for fluconazole.
Prevalence and management of amphotericin B deoxycholate-related toxicities during treatment of HIV-associated cryptococcal meningitis at South African hospitals (oral abstract).
Group D: Received Amphotericin B at dosage of 18.5 mg/kg dissolved in 3.7 ml of 5% dextrose solution intraperitoneally daily for first 7 days and then extract of Nigella sativa (500 mg/kg) was given orally daily for next 7 days.
High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: A randomized trial.
(5) For non-meningeal disseminated disease, an oral azole is first line, but amphotericin B can be utilized if there is vertebral involvement or rapid deterioration of clinical status.
An article recently published on this topic in Dynamics, the Journal of the Canadian Association of Critical Care Nurses (entitled "ALERT: Mix-ups between conventional and lipid formulations of amphotericin B can be extremely dangerous.'") provides an overview of incidents involving amphotericin B that have been reported to ISMP Canada.