amphotericin B


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Related to amphotericin B: liposomal amphotericin B

amphotericin B

 [am″fo-ter´ĭ-sin]
an antifungal agent and antibiotic used to treat deep-seated fungal infections, especially histoplasmosis, and also to treat cutaneous and mucocutaneous candidiasis. It may be applied topically or administered intravenously or by intracavitary instillation. Anorexia, chills, fever, and headache may occur as side effects. Renal damage with evidence of renal tubular acidosis occurs, but usually clears when the drug is discontinued.

am·pho·ter·i·cin

, amphotericin B (am'fō-tār'i-sin),
An amphoteric polyene antibiotic prepared from Streptomyces nodosus and available as the sodium deoxycholate complex; also a nephrotoxic antifungal agent used extensively in the treatment of systemic mycoses.

amphotericin B

/am·pho·ter·i·cin B/ (-ter´ĭ-sin) an antibiotic derived from strains of Streptomyces nodosus; effective against a wide range of fungi and some species of Leishmania.

amphotericin B

(ăm′fə-tĕr′ĭ-sĭn)
n.
An antibiotic derived from strains of the actinomycete Streptomyces nodosus and used to treat systemic fungal infections.

amphotericin B

[am′fəter′əsin]
an antifungal medication.
indication It is prescribed for topical or systemic use in the treatment of fungal infections.
contraindication Known hypersensitivity prohibits its use.
adverse effects When it is used systemically, among the most serious adverse reactions are anaphylaxis, thrombophlebitis, blood dyscrasia, nephrotoxicity, nausea, and fever; chills and shaking may occur on administration. With topical use, local hypersensitivity reactions are the most common adverse reactions.

amphotericin B

Infectious disease A heptaene macrolide antibiotic produced by the bacteria, Streptomyces nodosus, administered IV Effective against Blastomycosis dermatitidis, Candida, Coccidioides immitis, Cryptococcus neoformans, H capsulatum, Paracoccidioides braziliensis, Torulopsis glabrata Adverse effects Severe–fever, azotemia, nephrotoxicity, chills, headache, anorexia, N&V, diarrhea, kidney damage, BM suppression Lab Hypochromic normocytic anemia, neutropenia See Amphotec, Liposome.

Amphotericin B (Fengizone)

An antifungal medication, prescribed for topical or systemic use in treating fungal infections.

amphotericin B

a nephrotoxic antibiotic used in the treatment of systemic thrush, some types of onychomycosis and leishmaniasis

antifungal agent 

Any substance which destroys or prevents the growth of fungi. It is one of the antibiotic groups. There are several classes of antifungal drugs: Polyenes, which cause an increase in fungal cell wall permeability leading to its death. Examples: amphotericin B, natamycin, nystatin. Azoles, which act either by inhibiting the synthesis of ergosterol, a component of fungal cell wall or by causing direct wall damage. Examples: clotrimazole, econazole, fluconazole, itraconazole, ketoconazole, miconazole. Pyrimidines, which interfere with the normal function of fungal cells. Example: flucytosine. Syn antimycotic agent.

am·pho·ter·i·cin

, amphotericin B (amfō-teri-sin)
An amphoteric antibiotic and nephrotoxic antifungal agent used extensively to treat systemic mycoses.

amphotericin B

an antifungal antibiotic produced by Streptomyces nodosus, used to treat deep mycotic infections and also to treat cutaneous and mucocutaneous candidiasis. Potential nephrotoxicity limits its use.
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References in periodicals archive ?
Table: Effects of coadministration of amphotericin B and cyclosporine on renal functions of rabbit; Group A (Control) vs Group E (Amphotericin B + cyclosporine): Serum analysis:
27 In the current work therefore we evaluated the possible protective effects of Nigella sativa extract on nephrotoxicity produced by Amphotericin B in albino mice.
Six vials, each containing 50 mg of conventional non-lipid amphotericin B (Fungizone[R]), were available in each of the two ADCs in the ICU.
Following debridement, an induction phase of treatment with high doses of IV amphotericin B is generally initiated to achieve high drug concentrations.
AmBisome consists of amphotericin B intercalated into a unilamellar bilayer vesicle consisting of phospholipids and cholesterol and measuring <100 run in diameter.
For one of these, liposomal amphotericin B, the standard dose in invasive fungal infections is 3 mg/kg per day.
A decade of experience with blastomycosis and its treatment with amphotericin B.
Evidence reveals that topical ointment preparations of nystatin or amphotericin B treat angular cheilitis (strength of recommendation [SOR]: A, 2 small placebo-controlled studies).
Newark, NJ) announced it has licensed a topical formulation of its lead product, encochleated amphotericin B to Accentia, Inc.