auris infections to consider combination therapy with micafungin plus liposomal amphotericin
B in patients who fail monotherapy with micafungin.
We also gratefully acknowledge the pharmacy VicoFarma for donating the amphotericin
B used in this study and the Parana State Central Laboratory (LACEN) for providing clinical isolates.
Antileishmanial activity of liposome-encapsulated amphotericin
B in hamster and monkeys.
Johnson, "Intrathecal amphotericin
B: a 60-year experience in treating coccidioidal meningitis," Clinical Infectious Diseases, vol.
Effective induction therapy requires potent fungicidal drugs (amphotericin
B and flucytosine) [7, 17], which are often unavailable in low-resource, high-endemicity settings.
B binds to ergosterol, the major sterol in the fungal cell membrane, creating transmembrane channels with resultant increase in permeability of monovalent cations and cell death by osmotic lysis [13-15].
Conclusion: Iatrogenic acute kidney damage is a major cause of morbidity in experimental animals exposed to such nephrotoxic drugs like amphotericin
B and cyclosporine, used either alone or in combination.
The in vitro activity of amphotericin
b, itraconazole and voriconazole was evaluated against 44 isolates of Fusarium, by the disk diffusion test according to the methods provided in CLSI M38-A (16,17).
NAC species showed more resistance to fluconazole, voriconazole, caspofungin, micafungin, and amphotericin
B as compared to C.
B and surgery, in selected cases, are major treatment options.
Resistance to amphotericin
B most frequently occurs in C.
The most promising AfLT include ethanol, amphotericin
B or echinocandins.