A, Type 1 papillary renal cell carcinoma with well-formed fibrovascular core lined with a single layer of cuboidal cells with moderate
amphophilic cytoplasm.
The tumor was constituted of pleomorphic cells, with round-oval nuclei, some with prominent nucleolus, dispersed chromatin,
amphophilic or eosinophilic cytoplasm, with evident cell limits.
The crystalline style consists of mucoglobulin (Hyman 1967) and microscopically appears as an
amphophilic homogenous acellular substance cast within the lumen of the style sac.
The tumour cells showed ovoid nuclei, discernible nucleoli, occasional intranuclear inclusions, scant mitotic activity, and
amphophilic cytoplasm.
Histologically, cerebellar folia were separated consistently by thick sheets of neoplastic cells, which were round, 10-20 pm in diameter, with a small amount of well-defined eosinophilic to
amphophilic cytoplasm and round or cleaved nuclei with clumped chromatin and inconspicuous nucleoli (Figs 1A, 1B).
Blood vessels in the periphery of the necrotic areas were occluded by
amphophilic, amorphous material (emboli) (Figure 1D) that strongly stained with alcian blue and was interpreted as fibrocartilaginous emboli (Figure 1D inset).
There were also ganglion-like cells with abundant
amphophilic to basophilic cytoplasm (Figure 4).
The fibroblastic cells were spindle to stellate shaped with
amphophilic cytoplasm and uniform oval nuclei with small nucleoli.
The epithelioid cells were noted to have abundant
amphophilic cytoplasm, uniform, rounded nuclei with "salt and pepper" chromatin, and small nucleoli.
Microscopic sections of the mass revealed a poorly circumscribed growth of spindle cells showing
amphophilic cytoplasm and open chromatin with distended nuclear membranes (Figures 1 and 2).
The fungal conidia were round structures approximately 30-40 micrometers in diameter with 2 micrometers of thick pale basophilic cell walls and heterogeneous amorphous pale
amphophilic central material, consistent with immature Coccidioides immitis spherules (Figure 1).
Necrotic neurons were variously swollen and hypereosinophilic or shrunken with tinctorial changes including faded,
amphophilic, or eosinophilic cytoplasm (Figure 5).
