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Amphicrine carcinoma of the stomach must be differentiated from the gastric carcinoid with signet ring cells because of their divergent prognoses (1, 2); whereas the former shows dual differentiation in the majority of cells, the latter is composed of a major population of neuroendocrine cells with scattered signet ring cells.
(1, 2) However, in amphicrine carcinomas, such as the present case, the behavior as well as the treatment currently remain in dispute.