ampakines

ampakines

A class of drugs that act on nerve cell receptors to make them more responsive to the NEUROTRANSMITTER glutamate. Ampakines alter the ways in which a memory is encoded and modify the strength of the memory trace. A few small clinical trials have suggested that ampakines can significantly improve memory in elderly people. The duration of action is short.
References in periodicals archive ?
May 04, 2015: Cortex Pharmaceuticals Announces Publication of Research Results on the Use of Ampakines CX1739 in the Treatment of Respiratory Disorders 70
Ampakines had previously been shown to improve age-related cognitive deficits in rats as well as increase production of a key growth factor, brain-derived neurotrophic factor (BDNF) in the brain.
Cortex Pharmaceuticals added that the proceeds may be used to support its clinical development of ampakines for the treatment of central sleep apnea and opiate induced respiratory depression, commencing with a Phase 2A clinical study of CX1739, the lead ampakine, as well as to fund corporate general and administrative costs.
Ampakines, a new class of drugs developed by Lynch, are currently in clinical development for Alzheimer's disease and attention-deficit hyperactivity disorder (ADHD).
Studies of cells in the laboratory have shown that drugs called ampakines elevate production of BDNF.
Scientists in California are developing a class of experimental drugs call ampakines which flood the brain with a neurotransmitter that makes learning easy, improves memory and boosts alertness.
The drugs - called ampakines - work by boosting the levels of a brain chemical that makes it easier to learn and create memoriesDr Gary Lynch, who discovered the drug, explained: 'We all have the same computer but we're running with different voltage levels.
This brings our total portfolio on the AMPAKINEs to 17 issued and allowed patents, with 58 additional patent applications in various stages of review throughout the world.
Greer stated, "It is striking how well AMPAKINES enhance the activity of brain cells in the respiratory rhythm generator.
ONE US company has been working on a class of drugs called ampakines.
Research conducted at the University of California, Irvine (Irvine, CA) demonstrates that AMPAKINEs can increase the production of the important neurotrophic factors BDNF (brain derived neurotrophic factor) and NGF (neuronal growth factor) in critical areas of the brain involved in memory.