The team, led by Lynch, Julie Lauterborn, and Linda Palmer, wanted to know whether dendritic retraction was already underway in 13-month-old or "middle-aged" rats and, if it was, could they reverse it by giving rats a compound called an ampakine
Cortex Pharmaceuticals added that the proceeds may be used to support its clinical development of ampakines
for the treatment of central sleep apnea and opiate induced respiratory depression, commencing with a Phase 2A clinical study of CX1739, the lead ampakine
, as well as to fund corporate general and administrative costs.
Drugs like Ampakine
CX717 may prevent harmful effects of sleep deprivation and enhance attention span and alertness.
As previously announced, in June 2011 Cortex entered into a new agreement with Servier to sell its remaining rights to the jointly discovered AMPAKINE
Randomized, double-blind, placebo-controlled international clinical trial of the Ampakine
CX516 in elderly participants with mild cognitive impairment: a progress report.
is currently being tested in people with Alzheimer's disease.
Increased net losses in the current year periods reflect development expenses for the AMPAKINE
(R) compound, CX717 and increased preclinical research and development of the AMPAKINE
Unfortunately, the first generation drug faltered in clinical trials but the firm is moving ahead with a more potent ampakine
For example, treatment of healthy human subjects with an ampakine
, which enhances LTP, improved performance in a dose-dependent manner.
There also is evidence that ampakine
, an investigational drug that modulates glutaminergic alpha-amino-3-hydroxy-5methylisoxazole-4-propionic acid (AMPA) receptor activity, improves "many domains of cognitive function," Dr.
compounds are a very interesting class of molecules," said Vincent F.
It was invented at UC Irvine - an ampakine
compound trademarked as a pill under the name Ampalex.