ampakine


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ampakine

An AMPA-type glutamine receptor agonist (e.g., CX516) which facilitates synaptic transmission by binding to glutamate and enhancing long-term potentiation, a critical component in memory. Amakines enhance the activity of AMPA receptor-rich neurons by amplifying neural signals, and are reported to improve memory in early trials in Alzheimer’s disease and schizophrenia.

ampakine

Neuropharmacology Any compound that facilitates synaptic transmission by binding to glutamate and enhance long-term potentiation, a critical component in long term memory, by enhancing the activity of AMPA receptor-rich neurons which enhance AMPA receptor activity by amplifying neural signals generated by glutamate binding; ampakines improve memory in early trials in Alzheimer's disease, schizophrenia See AMPA receptor, Long-term potentiation.
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These patents are key for developing the AMPAKINE technology for the potential treatment of a variety of clinical indications."
Additionally, the companies have signed a memorandum of understanding (MOU) for the rights to the AMPAKINE CX1739 for neurodegenerative diseases in South Korea.
29 March 2010 - US-based developer of small molecule compounds Cortex Pharmaceuticals Inc (OTC: CORX) announced on Friday that it has entered into an agreement with Biovail Laboratories International SRL in which Biovail acquired certain AMPAKINE compounds and the rights to the patent filing for respiratory depression and vaso-occlusive crises associated with sickle cell disease.
(Irvine, CA; 949-727-3157) announced that it has received three patents and three notices of allowances for patents in its AMPAKINE program.
M2 EQUITYBITES-August 25, 2011-Cortex Pharmaceuticals Inc awarded US patent for AMPAKINE molecules for respiratory depression(C)2011 M2 COMMUNICATIONS http://www.m2.com
"Cortex and its collaborators at UC Irvine are in the process of initiating a long term experiment in which rats will receive an AMPAKINE in their drinking water for four to eight months.
M2 EQUITYBITES-August 25, 2011-Cortex awarded patent for the use of AMPAKINE molecules to treat respiratory depression(C)2011 M2 COMMUNICATIONS http://www.m2.com
For example, treatment of healthy human subjects with an ampakine, which enhances LTP, improved performance in a dose-dependent manner.
There also is evidence that ampakine, an investigational drug that modulates glutaminergic alpha-amino-3-hydroxy-5methylisoxazole-4-propionic acid (AMPA) receptor activity, improves "many domains of cognitive function," Dr.
The team, led by Lynch, Julie Lauterborn, and Linda Palmer, wanted to know whether dendritic retraction was already underway in 13-month-old or "middle-aged" rats and, if it was, could they reverse it by giving rats a compound called an ampakine. Ampakines had previously been shown to improve age-related cognitive deficits in rats as well as increase production of a key growth factor, brain-derived neurotrophic factor (BDNF) in the brain.
Cortex Pharmaceuticals added that the proceeds may be used to support its clinical development of ampakines for the treatment of central sleep apnea and opiate induced respiratory depression, commencing with a Phase 2A clinical study of CX1739, the lead ampakine, as well as to fund corporate general and administrative costs.
Katz, "Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome," The Journal of Neuroscience, vol.