amoebapore

a·moe·ba·pore

(ă-mē'ba-pōr),

An active peptide released from Entamoeba histolytica that can insert ion channels into liposomes and that has cytolytic and bactericidal activities.

[amoeba + G. poros, passageway]

Farlex Partner Medical Dictionary © Farlex 2012

a·moe·ba·pore

(ă-mē'bă-pōr)

An active peptide released from Entamoeba histolytica that can insert ion channels into liposomes and possesses cytolytic and bactericidal activities.

[amoeba + G. poros, passageway]

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

amoebapore

, amebapore (ă-mē′bă-por″) [ amoeba + pore]

A family of three pore-forming peptides (amoebapore A [AP-A], AP-B, and AP-C). They insert into the membranes of bacteria or eukaryotic cells and form tiny holes that result in lysis of the target cells.

References in periodicals archive ?

Adherence to colonic mucosa is conducive to the continued reproduction of parasites and tissue damage by the products secreted by amoebae, such as the pore-forming peptide amoebapore [66], which permits a massive influx of extracellular Ca+2 that is combined with the release of amoebic proteases at the site of contact, with the subsequent degradation of substrates.

Incubation of amoebae with type-I collagen not only promotes collagenase activity but also increases the secretion of other CPs [15], and together with Ca2+, type-I collagen can induce the activation of several amoebic genes related to virulence factors, such as amoebapore C and EhCP5, along with the stress-induced protein HSP70 and the ribosomal protein L27a [138].

Using silenced strains, the authors reported that this phenomenon occurred independently of the cytolytic amoebapore but required galactose-inhibitable parasite adhesion, likely involving amoebic Gal/GalNAc lectin, and active E.

In thiswork, the authors postulate that amoebae first bind to intestinal epithelial cells and then lyse those cells through the action of amoebapore [175, 176].

histolytica, the only available strategy requires the use of the G3 strain in which the amoebapore is silenced as a genetic background to perform the knockdown of the protease gene.

Mirelman, "Antisense inhibition of amoebapore expression in Entamoeba histolytica causes a decrease in amoebic virulence," Molecular Microbiology, vol.

Proteases from entamoeba spp. and pathogenic free-living amoebae as virulence factors

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