amodiaquine


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amodiaquine

 [am″o-di´ah-kwin]
an antimalarial, administered orally as the hydrochloride salt in the treatment of malaria, especially falciparum malaria.
References in periodicals archive ?
Resistance to both chloroquine and amodiaquine has been mainly associated with a single K76T mutant allele in the pfcrt gene (22-24).
Keywords * Malaria * Chloroquine * Amodiaquine * Drug resistance
Efficacy and safety of artemether + lumefantrine, artesunate + sulphamethoxypyrazine-pyrimethamine and artesunate + amodiaquine and sulphadoxine-pyrimethamine + amodiaquine in the treatment of uncomplicated falciparum malaria in Bangui, Central African Republic: A randomized trial.
The result of our present study showed that Vitamin E provided a protective environment against the oxidative stress induced by amodiaquine in the ovary through its antioxidant activity.
Table 3 Semantic MEDLINE recall * of DynaMed preventive intervention reference standard for malaria ([dagger]) Recall in Semantic MEDLINE Secondary Primary analysis analysis (other DynaMed prevention intervention (PREVENTS) predicates) Long sleeves FN FN Long pants FN FN Window screens FN FN Mosquito nets TP N/A Insecticide-treated clothes FN FN Insecticide-treated nets TP N/A Insect repellent TP N/A Indoor spraying FN FN Insecticide treatment of livestock FN FN Atovaquone/proguanil TP N/A Trimethoprim-sulfamethoxazole FN FN "Antimalarial agents" TP N/A Artesunate plus amodiaquine or sulfadoxine-pyrimethamine FN TP Mefloquine TP N/A Sulfadoxine-pyrimethamine TP N/A Amodiaquine TP N/A Pyrimethamine plus dapsone FN TP Routine malaria chemoprophylaxis (i.
Professor Mueller said the most effective drug combination in the trial was the long-lasting antimalarials sulfadoxine/pyrimethamine and amodiaquine (SP-AQ), which act against the two most lethal species of malaria parasite, Plasmodium falciparum and Plasmodium vivax.
Low efficacy of the combination artesunate plus amodiaquine for uncomplicated falciparum malaria among children under 5 years in Kailahun, Sierra Leone.
Antimalarial drugs include chloroquine, amodiaquine, pyrimethamine, sulfonamides, quinine, quinidine, tetracyclines, mefloquine, and artemisinin (usually in combination with other anti-malarials).
Cross-resistance between CQ and amodiaquine (AQ) may be a contributory reason, owing to the similarities in their modes of action.
6) Drugs consisted of nine antimalarials, to include chloroquine, sulfadoxine-pyrimethamine, mefloquine, amodiaquine, artemether, artesunate, dihydroartemisinin and two artemisinin-based combination therapies (artemether-lumefantrine and artesunate-amodiaquine); two antimycobacterials, to include isoniazid and rifampicin; and two antibiotics, to include ciprofloxacin and erythromycin.
Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzymespecific probe substrate.