amodiaquine


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amodiaquine

 [am″o-di´ah-kwin]
an antimalarial, administered orally as the hydrochloride salt in the treatment of malaria, especially falciparum malaria.
References in periodicals archive ?
A study of toxicity and differential gene expression in murine liver following exposure to anti-malarial drugs: Amodiaquine and sulphadoxine-pyrimethamine.
Ahmed et al., "Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria," Antimicrobial Agents and Chemotherapy, vol.
Tahar et al., "Efficacy of sulfadoxine-pyrimethamine, amodiaquine, and sulfadoxine-pyrimethamine- amodiaquine combination for the treatment of uncomplicated falciparum malaria in the urban and suburban areas of Brazzaville (Congo)," Acta Tropica, vol.
Antimalarial drug regimens prescribed n (%) Non-artemisinin monotherapies (NAMTs) 8 (2.4) Proguanil 5 (1.5) Sulphadoxine-Pyrimethamine 2 (0.6) Amodiaquine 1 (0.3) Artemisinin monotherapies (AMTs) 6 (1.8) Artesunate 2 (0.6) Arteether 2 (0.6) Artemether 1 (0.3) Dihydroartemisinin 1 (0.3) Artemisinin combination therapies (ACTs) 319 (95.8) Artemether/Lumefantrine 269 (80.8) Artesunate/ Meflo quine 20 (6.0) Dihydroartemisinin/Piperaquine 16 (4.8) Artesunate/Amo diaquine 8 (2.4) Artesunate/Piperaquine 4(1.2) Artemether/Lumefantrine + Sulphadoxine-Pyrimethamine 1 (0.3) Artesunate/Sulphadoxine-Pyrimethamine + Proguanil 1 (0.3) Table 3: Drug prescribing indicators.
Keywords * Malaria * Chloroquine * Amodiaquine * Drug resistance
Efficacy of the amodiaquine + sulfadoxine-pyrimethamine combination and of chloroquine for the treatment of malaria in Cordoba, Colombia, 2006.
There are several antimalarials targeting the blood forms of P vivax, such as chloroquine, amodiaquine, artesunate, artemether, lumefantrine, dihydroartemisinin, piperaquine, chloroquine remains the most widely used as first-line treatment for this species (2,7).
falciparum malaria cases are artemether-lumefantrine (AM-LF), artesunatemefloquine (AS-MQ), artesunate-sulfadoxine-pyrimethamine (AS-SP), dihydroartemisinin-piperaquine, and artesunate amodiaquine (2).
Sanofi added that more than 1.7m treatments of its ArteSunate AmodiaQuine Winthrop (ASAQ Winthrop, which is a fixed dose artemisinin-based combination therapy) is being manufactured with semisynthetic artesunate in Morocco and are being shipped from its distribution centre to Burkina Faso, Burundi, Congo, Liberia, Niger and Nigeria.
Artemisinin with an endoperoxide sesquiterpene lactone structure is unlike those of any other known antimalarials (mefloquine, amodiaquine, and chloroquine) that kills all stages of the parasite by a reductive interaction with free heme, resulting in generation of some types of free radicals that could alkylate parasite proteins and damage membranes [8].
White, "Pharmacokinetics of quinine, chloroquine and amodiaquine: clinical implications," Clinical Pharmacokinetics, vol.