amlodipine besylate


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amlodipine besylate

Norvasc

Pharmacologic class: Calcium channel blocker

Therapeutic class: Antihypertensive

Pregnancy risk category C

Action

Inhibits influx of extracellular calcium ions, thereby decreasing myocardial contractility, relaxing coronary and vascular muscles, and decreasing peripheral resistance

Availability

Tablets: 2.5 mg, 5 mg, 10 mg

Indications and dosages

Essential hypertension, chronic stable angina pectoris, and vasospastic angina (Prinzmetal's angina)

Adults: 5 to 10 mg P.O. once daily

Dosage adjustment

• Hepatic impairment
• Elderly patients

Off-label uses

• Pulmonary hypertension
• Raynaud's disease

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:
• aortic stenosis, severe hepatic impairment, heart failure
• elderly patients
• pregnant or breastfeeding patients
• children.

Administration

• Be aware that this drug may be given alone or with other drugs to relieve hypertension or angina.

Adverse reactions

CNS: headache, dizziness, drowsiness, light-headedness, fatigue, weakness, lethargy

CV: peripheral edema, angina, bradycardia, hypotension, palpitations

GI: nausea, abdominal discomfort

Musculoskeletal: muscle cramps, muscle pain or inflammation

Respiratory: shortness of breath, dyspnea, wheezing

Skin: rash, pruritus, urticaria, flushing

Interactions

Drug-drug.Beta-adrenergic blockers: increased risk of adverse effects

Fentanyl, nitrates, other antihypertensives, quinidine: additive hypotension

Drug-behaviors.Acute alcohol ingestion: additive hypotension

Patient monitoring

Monitor patient for worsening angina.
• Monitor heart rate and rhythm and blood pressure, especially at start of therapy.

Assess for heart failure; report signs and symptoms (peripheral edema, dyspnea) to prescriber promptly.

Give sublingual nitroglycerin, as prescribed, if patient has signs or symptoms of acute myocardial infarction (especially when dosage is increased).

Patient teaching

• If patient also uses sublingual nitroglycerin, tell him he can take nitroglycerin as needed for acute angina.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• As appropriate, review all other significant adverse reactions, especially those related to the drugs and behaviors mentioned above.

amlodipine besylate

(ăm;-lō′də-pēn′)
n.
A calcium channel blocker that acts as a coronary vasodilator, used to treat hypertension and coronary artery disease.

amlodipine besylate

Norvasc® Cardiology A CCB used to treat HTN and angina pectoris. See ACT, Calcium channel blocker, PRAISE.

amlodipine besylate (amlō´dipēn bes´əlāt),

n brand name: Norvasc;
drug class: calcium channel blocker;
action: inhibits calcium ion influx across cell membrane during cardiac depolarization; produces relaxation of coronary vascular smooth muscle and dilates coronary arteries; decreases SA/AV node conduction;
uses: hypertension as a single agent or in combination with other antihypertensives, chronic stable angina pectoris, vasospastic angina.

amlodipine besylate

a long-acting dihydropyridine calcium channel blocking agent, used in the treatment of hypertension.
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5mg once daily and the second group received Amlodipine besylate (AMLO) 5mg once daily throughout the study.
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Reddy's Laboratories (NYSE:RDY) revealed on Thursday the launch of its Amlodipine Besylate and Benazepril Hydrochloride capsules (5 mg/40 mg and 10 mg/40 mg) in the US market on 5 July 2011.
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Specialty pharmaceutical company Par Pharmaceutical Companies Inc (NYSE:PRX) said on Monday that it has commenced the shipment of all strengths (5/320mg and 10/320mg strengths) of amlodipine besylate and benazepril hydrochloride capsules, which are indicated for the treatment of hypertension in patients not adequately controlled on monotherapy with either agent.
23 July 2010 - Japanese Nippon Boehringer Ingelheim Co Ltd and Astellas Pharma Inc (TYO: 4503) said today they have received approval for the manufacturing and distribution of Micamlo Combination Tablets AP, a combination drug of telmisartan (Micardis), an angiotensin II receptor blocker (ARB) and amlodipine besylate, a calcium channel blocker (CCB).
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