amlodipine


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Related to amlodipine: Bisoprolol

amlodipine

 [am-lo´dĭ-pēn]
a calcium channel blocking agent administered orally in the form of the besylate salt in treatment of hypertension and chronic stable and vasospastic angina.

amlodipine

/am·lo·di·pine/ (am-lo´dĭ-pēn″) a calcium channel blocking agent used as the besylate salt in the treatment of hypertension and chronic stable and vasospastic angina.

amlodipine

[amlō′dipēn]
a calcium channel blocker administered orally in the form of the besylate salt in the treatment of hypertension and chronic stable and vasospastic angina.

amlodipine

A drug used in the treatment of ANGINA PECTORIS and high blood pressure (HYPERTENSION). A brand name is Istin.

amlodipine

calcium channel-blocking agent with similar actions to nifedipine (see Table 1)
Table 1: Drug treatment of hypertension
Drug typeExamplesComments
Thiazide diureticsBendroflumethiazide
Chlortalidone (Hygroton)
Cyclopenthiazide (Navidrex)
Indapamide (Natrilix)
Metolazone (Metenix 5)
Xipamide (Diurexan)
Indicated for hypertension in elderly patients
Tend to exacerbate diabetes, gout, systemic lupus erythematosus
May cause postural hypotension
Beta-blockers ('.…lol')Propranolol (Inderal)
Acebutolol (Sectral)
Atenolol (Tenormin)
Bisoprolol (Cardicor)
Carvedilol (Eucardic)
Celiprolol (Celectol)
Esmolol (Brevibloc)
Labetalol (Transdate)
Metoprolol (Betaloc)
Nadolol (Corgard)
Nebivol (Nebilet)
Oxprenolol (Trasicor)
Pindolol (Visken)
Sotalol (Beta-Cardone)
Timolol (Betim)
Should not be used by patients with asthma or bradycardia or hypotension
Should be avoided in patients with a history of Raynaud's
May cause distal paraesthesia, impotence, dizziness and exacerbation of psoriasis
Angiotensin-converting enzyme (ACE) inhibitors ('..…pril')Captopril
Cilazapril (Vascace)
Enalapril (Innovace)
Fosinopril (Staril)
Imidapril (Tanatril)
Lisinpril (Carace; Zestril)
Moexipril (Perdix)
Perindopril (Coversyl)
Quinapril (Accupro)
Ramipril (Tritace)
Trandolapril (Gopten)
Used only with care in patients taking diuretics, or those with peripheral vascular disease, generalized atherosclerosis and kidney disease
May cause profound hypotension, persistent cough, renal impairment, angioedema and pruritic rashes
Angiotensin II receptor antagonists ('.…sartan')Candesartan (Animax)
Eprosartan (Teveten)
Irbesartan (Aprovel)
Losartan (Cozaar)
Olmesartan (Olmetec)
Telmisartan (Micardis)
Valsartan (Diovan)
Used only with caution in patients with aortic or mitral valve stenosis, or renal artery disease
Tend not to be effective in Afro-Caribbean patients with left ventricular hypertrophy
Calcium-channel blockers ('.…dipine')Amlodipine (Istin)
Diltiazem (Calcicard)
Felodipine (Plendil)
Isradipine (Prescal)
Lacidipine (Motens)
Lercadidipine (Zanidip)
Nicardipine (Cardene)
Nifedipine (Adalat)
Nimodipine (Nimotrop)
Nisoldipine (Syscor MR)
Verapamil (Cordilox)
May cause abdominal pain, nausea, flushing, oedema, headache, dizziness, constipation and sleep disturbance
Alpha-blockers ('.…zosin')Doxazosin (Cardura)
Indoramin (Baratol)
Prazosin (Hypovase)
Terazosin (Hytrin)
Should not be used in patients with urinary incontinence
Tend to cause hypotension, dizziness, vertigo, headache, fatigue

Where antihypertensive drugs are used in combination, a rule-of-thumb guide indicates:

A + C (ACE inhibitors + calcium channel blockers)

B + D (beta-blockers + diuretics)

References in periodicals archive ?
To determine whether a random steady-state plasma amlodipine concentration and Z-FHL/HHL ratio in the clinic setting could independently indicate adherence to medication for BP control.
The US Food and Drug Administration (FDA) approved the Indian pharma firms's abbreviated new drug application (ANDA) for Olmesartan Medoxomil and Amlodipine tablets for the treatment of hypertension, alone or with antihypertensive agents to lower blood pressure.
Purpura, bleeding, calcium channel blockers, amlodipine.
Conclusion: The combination therapy of valsartan with amlodipine significantly lowers the albuminuria in chronic Kidney disease and reduce the progression of disease as compared to Valsartan alone therapy.
The aim of this study was to determine whether the GNB3 C825T polymorphism can influence antihypertensive response to amlodipine and telmisartan monotherapy in Chinese EH patients.
Amlodipine significantly changed all the three IOP and SBP parameters.
Amlodipine is given in the dose of 5-10 mg once daily as it has a long duration of action.
After administration of a single dose of amlodipine to 4 groups of animals the mice were subjected to electro-convulsions (each group with a constant current intensity ranging between 5 - 9 mA), the threshold for maximal electro-convulsions was recorded for 3 different doses of amlodipine (5, 10 and 20 mg/kg).
The patient was hypertensive since 1 year and was under medication atenolol 50 mg and amlodipine 5 mg once daily.
There have been several studies comparing the antihypertensive efficacy and tolerability of a fixed combination of losartan (LST) and hydrochlorothiazide (HCTZ) with those of amlodipine besylate (AMLO) in westerners.
Previous smaller-scale studies have reported that blood pressure drugs help lower the risk of dementia, but the new study will specifically test the effects of Amlodipine.
Within the normal-weight category, benazepril plus amlodipine was associated with significantly decreased risk for the composite endpoint (HR, 0.