Kirby-Bauer antibiotic testing of Aeromonas species revealed antibiotic susceptibility to amikacin, aminosidine
, third-generation cephalosporins, second-generation quinolones, colistin, gentamicin, spectinomycin, trimethoprim-sulphonamides, and tetracycline.
Cure at the end of follow up was achieved in 23 (77%), 28 (93%), and 29 (97%) patients with 12,16 and 20 mg aminosidine /kg/day respectively, and in 19 (63%) patients given sodium stibogluconate.
Treatment of visceral leishmaniasis (kalaazar) with aminosidine (paromomycin) antimonial combinations, a pilot study in Bihar, India.
Treatment of visceral leishmaniasis in Kenya by aminosidine alone or combined with sodium stibogluconate.
Aminosidine plus sodium stibogluconate for the treatment of Indian kala-azar: a randomized dose finding clinical trial.
Of those drugs in the current pipeline, aminosidine
(developed by the Institute for OneWorld Health) was submitted for registration in India for the prevention of leishmaniasis and was approved only a few weeks ago.
A range of treatment options exists in visceral leishmaniasis, which include two pentavalent antimonials (meglumine antimoniate and sodium stibogluconate), four formulations of AmB, aminosidine
(paromomycin), pentamidine, and the new oral agent miltefosine (9,10).
pentavalent antimonials, amphotericin B, aminosidine
, or allopurinol) is not a practical control policy, not only because of the prohibitive cost involved but also because of high relapse rates (up to 74% ) among treated and clinically cured dogs.