aminoquinoline


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aminoquinoline

 [ah-me″no-kwin´o-lēn]
a heterocyclic compound derived from quinoline by the addition of an amino group; the 4-aminoquinoline and 8-aminoquinoline derivatives are groups of antimalarial agents.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
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Franks noted that the aminoquinoline antimalarials represent first-line oral therapy.
Studies of complex formation between the bromophenol blue and some important aminoquinoline antimalarials.
Mutations within the Plasmodium falciparum multidrug-resistant (Pfmdr)1 gene principally the N86Y, Y184F, S1034C, N1042D, and D1246Y were shown to play a modulatory role in further decreasing sensitivity to chloroquine as well as other aminoquinolines such as amodiaquine (AQ) and mefloquine [13, 14].
It took 15 years to observe a loss of efficacy with aminoquinolines. Quinine, isolated from Cinchona, is still useful despite more than 350 years of continuous use.
Antimalarial drug resistance has spread and intensified over the last 15-20 years, leading to a dramatic decline in the efficacy of most antimalarial drugs including aminoquinolines, halofantrine, sulfadoxine-pyrimehtamine etc [6,10,76,50,55].
Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, Inhibition of -hematin formation, and antiplasmodial activity.