Franks noted that the aminoquinoline
antimalarials represent first-line oral therapy.
We plan to develop new caged neuroactive amino acids based on Laport symmetry-allowed aminoquinoline
constructs with large two-photon cross-sections, high water solubility and minimal pharmacological interference.
Studies of complex formation between the bromophenol blue and some important aminoquinoline
Antimalarial drug resistance has spread and intensified over the last 15-20 years, leading to a dramatic decline in the efficacy of most antimalarial drugs including aminoquinolines
, halofantrine, sulfadoxine-pyrimehtamine etc [6,10,76,50,55].
APT's patented technology is based on targeted administration of aminoquinolines
to inflamed tissues.
Of the remaining compound class, spirotetrahydro-beta-carbolines or spiroindolones have favorable physical and chemical properties for drug development as well as a mechanism of action distinct from the currently used therapies based on aminoquinolines
and artemisinin derivatives," he added.