aminopterin


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aminopterin

Oncology A folic acid antagonist and inhibitor of dihydrofolate reductase; it is a potent cytotoxic agent fomerly used to manage leukemia; it has been replaced by MTX. See Methotrexate.

aminopterin

(am-ĭ-nop′tĕr-ĭn)
A folic acid antagonist used to treat acute leukemia.
References in periodicals archive ?
The federal government prohibits using aminopterin for killing rodents in the United States.
Attempted abortion with aminopterin (4-aminnpteroglutamic acid).
Initiation of a Phase II trial of aminopterin for treatment of recurrent endometrial cancer.
2] in DMEM (Eurobio) supplemented with 100 mL/L heat-inactivated fetal calf serum (FCS; BioWhittaker), 2 mmol/L glutamine, and 50 mL/L hypoxanthine aminopterin thymidine (FCS medium).
Also during the quarter, ILEX initiated a Phase II clinical trial of aminopterin in patients with persistent and recurrent endometrial cancer who have failed prior therapy.
First studied in 1948, aminopterin was the first drug to demonstrate the effectiveness of folate inhibition for cancer therapy.
Production of functional human T-T hybridomasin selection medium lacking aminopterin and thymidine.
NASDAQ: ILXO) today announced the initiation of a Phase II trial of aminopterin, a potent antifolate that effectively inhibits cancer cell replication.
Splenocytes were fused with a nonsecretor cell line sp2/0 and plated into Dulbecco's modified Eagle's medium containing hypoxanthine, aminopterin, and thymidine with 150 mL/L fetal bovine serum.
Researchers at the University of Texas Southwestern Medical Center at Dallas received a three-year grant to begin Phase II clinical trials of the ILEX compound, Aminopterin.
4 [micro]mol/L aminopterin, and 16 [micro]mol/L thymidine (Gibco BRL).