aminopeptidase


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Related to aminopeptidase: leucine aminopeptidase

a·mi·no·pep·ti·dase

(ă-mē'nō-pep'ti-dāz),
Enzyme that catalyzes the breakdown of a peptide, removing the amino acyl residue at the amino end of the chain (that is, an n-exopeptidase); found in intestinal secretions.

aminopeptidase

(ə-mē′nō-pĕp′tĭ-dās′, -dāz′, ăm′ə-)
n.
Any of various enzymes that catalyze the hydrolysis of the terminal peptide bond of a polypeptide from the end that contains a free amino group.

aminopeptidase

Any of the hydrolases–enzymes, which catalyze the removal of amino terminal amino acids or dipeptides from a protein or peptide

a·mi·no·pep·ti·dase

(ă-mē'nō-pep'ti-dās)
[EC sub-group 3.4.11] Enzyme catalyzing the breakdown of a peptide, removing the aminoacid at the amino end of the chain (i.e., an exopeptidase); found in intestinal secretions.

aminopeptidase

an enzyme that catalyses the sequential hydrolysis of amino acids in a polypeptide chain from the N-terminal.
References in periodicals archive ?
We analyzed mRNA expression levels of Filamin 3 and Aminopeptidase N by RT-qPCR as previously reported (17).
2D = grown on plastic, 2.5D = grown on transwell inserts, 3D = grown in matrigel sandwich, OAT = organic anion transporter, MRP = multidrug resistance protein, OCT = organic cation transporter, CTR1 = copper transporter 1, MATE = multidrug and toxin extrusion protein, OCTN = organic cation/ carnitine transporter, PGP = multidrug resistance protein/[gamma]-glycoprotein, BCRP = breast cancer resistance protein, SGLT = sodium/glucose co-transporter, GLUT1 = glucose transporter 1, CUBN = cubilin, AQP1 = aquaporin 1, GGT1 = y-glutamyltransferase 1, ALPL = alkaline phosphatase, LAP3 = leucine aminopeptidase 3, BF = bright field, RFU = relative fluorescence unit.
Matsumoto et al., "Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells," Journal of Biochemistry, vol.
Keller, "Vasopressin is a physiological substrate for the insulin-regulated aminopeptidase IRAP," American Journal of Physiology-Endocrinology and Metabolism, vol.
Trichoplusia ni resistance to Cry1Ac toxin in this strain was related to aminopeptidase N (APN1 and APN6) genes by a trans-regulatory mechanism, where APN1 was down-regulated and APN6 was up-regulated (Zhang et al.
Expression of ENPEP, the gene which encodes aminopeptidase A, a major Ang II metabolizing enzyme, was expressed at a moderate level in normal lung tissue with a statistically significant (p < 0.001, corrected for multiple comparisons, Table 2) 32% reduction in its expression in lung tumor tissue (Figure S1).
Jardinaud et al., "First discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [125I]RB 129," Neuroscience, vol.
Additionally and according to our in silico analysis, it seems that albumin fraction contains encrypted peptides that inhibit the dipeptidyl aminopeptidase IV (DPP-IV) (EC 3.4.14.5) and activate the ubiquitin-mediated proteolysis.
Aminopeptidase A (APA) is an enzyme that hydrolyzes the N-terminal amino acid of peptides and expressed in both periphery and brain.
Enriched genes in annotation cluster 1 also include aminopeptidases that hydrolyse antigenic peptides for MHC class I peptide binding and antigen presentation (e.g., endoplasmic reticulum aminopeptidase ERAP1 and ERAP2), peptide transporter genes (e.g., transported associated with antigen processing, TAP2), and other genes involved in the antigen processing and presentation pathway (e.g., TAP binding protein, TAPBPL; [[beta].sub.2] microglobulin, B2M; CD74).
Kain et al., "Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis," Cancer Research, vol.