aminolevulinic acid


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Related to aminolevulinic acid: porphyria

aminolevulinic acid

 (ALA) [ah-me″no-lev″u-lin´ik]
δ-aminolevulinic acid; a precursor of porphyrins and hemoglobin; serum levels of this acid are elevated in lead poisoning and urinary levels are increased in some porphyrias. The hydrochloride salt is used as a topical photosensitizer in the treatment of nonhyperkeratotic actinic keratoses.

aminolevulinic acid

Oncology A drug used in photodynamic therapy which is absorbed by tumor cells and activated when exposed to light, killing the cells. See Photodynamic therapy.
References in periodicals archive ?
In all patients, an aminolevulinic acid (ALA) solution was applied to the entire face for 1 hour, followed by intense pulsed light (IPL) with a 560-nm filter at 28-32 J/c[m.sup.2], with a double pulse of 3 milliseconds and 6 milliseconds and a 10-millisecond delay.
Key secondary and exploratory endpoints evaluated reductions in neurotoxic heme intermediates, aminolevulinic acid and porphobilinogen, usage of hemin, symptoms of AHP, such as pain, nausea, and fatigue, as well as impact on quality of life.
Field Treatment of Actinic Keratoses Efficacy % With % With Complete Clearance Reduction diclofenac (Solaraze gel, 3%) 47% 79% 5-fluorouracil (Carac cream, 0.5%) 52% 90% imiquimod (Aldara cream, 5%) 82%-87% ~90% or greater photodynamic therapy (aminolevulinic acid 66% (8 weeks) NA [Levulan Kerastick for topical solution, 20%]) 72% (12 weeks) NA Cost Quantity Cost diclofenac, 3% 60 g $100 5-fluorouracil, 0.5% 30 g $100 imiquimod, 5% 12 packets $150 photodynamic therapy (aminolevulinic acid) 1 applicator $106.25 * * Cost is based on data from 2002 Red Book.
(NASDAQ: ALNY) has completed a rolling submission of a New Drug Application to the US Food and Drug Administration for givosiran, an investigational RNAi therapeutic targeting aminolevulinic acid synthase 1 (ALAS1) in development for the treatment of acute hepatic porphyria, the company said.
Alnylam Pharmaceuticals announced that the Company presented updated results from the ongoing Phase 1/2 open-label extension study of givosiran, an investigational RNAi therapeutic, targeting aminolevulinic acid synthase 1 for the treatment of acute hepatic porphyria.
Aminolevulinic acid dehydratase genotype mediates plasma levels of the neurotoxin, 5-aminolevulinic acid, in lead-exposed workers.
- US-based RNAi therapeutics company Alnylam Pharmaceuticals, Inc.'s (NASDAQ: ALNY) ENVISION Phase 3 study of givosiran, an investigational RNAi therapeutic targeting aminolevulinic acid synthase 1 (ALAS1) in development for the treatment of acute hepatic porphyria, met its primary efficacy endpoint and the majority of secondary endpoints, the company said.
Alnylam Pharmaceuticals announced positive topline results from the interim analysis of the ENVISION Phase 3 Study of givosiran, an investigational RNAi therapeutic targeting aminolevulinic acid synthase 1, or ALAS1, for the treatment of acute hepatic porphyria, or AHP.
cPDT uses artificial light sources, but dPDT has been demonstrated to have at least comparable results/' The technique involves degreasing the face, gentle curettage of any thicker lesions, and application of aminolevulinic acid for 60 minutes.
DMSA-PbU has been found to be more strongly related to urinary aminolevulinic acid (12) and a better predictor of lead-related symptoms, particularly of total symptom scores and neuromuscular symptoms, than other lead biomarkers, including PbB (15).
SAN FRANCISCO -- Broad application of 20% aminolevulinic acid in conjunction with photodynamic therapy can be followed by "mop-up" spot cryotherapy in a novel combination approach to widespread actinic keratoses.