aminolevulinic acid


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Related to aminolevulinic acid: porphyria

aminolevulinic acid

 (ALA) [ah-me″no-lev″u-lin´ik]
δ-aminolevulinic acid; a precursor of porphyrins and hemoglobin; serum levels of this acid are elevated in lead poisoning and urinary levels are increased in some porphyrias. The hydrochloride salt is used as a topical photosensitizer in the treatment of nonhyperkeratotic actinic keratoses.

aminolevulinic acid

/ami·no·lev·u·lin·ic ac·id/ (ALA) (-lev″u-lin´ik) δ-aminolevulinic acid; an intermediate in the synthesis of heme; blood and urinary levels are increased in lead poisoning, and urinary levels are increased in some porphyrias. The hydrochloride salt is used as a topical photosensitizer in the treatment of nonhyperkeratotic actinic keratoses.

aminolevulinic acid

a photochemotherapeutic agent.
indication It is used to treat nonhyperkeratotic actinic keratosis of the face and scalp.
contraindication Known hypersensitivity to porphyrins contraindicates this drug's use.
adverse effects Side effects include crusts, hypopigmentation or hyperpigmentation, ulceration, pain, itching, bleeding, and pustules at the site of application.

aminolevulinic acid (ALA)

[am′inōlev′o̅o̅lin′ik]
the aliphatic precursor of heme. It is formed in the body from the condensation of glycine and succinyl coenzyme A and undergoes further condensation to form porphobilinogen. Aminolevulinic acid may be detected in the urine of some patients with porphyria, liver disease, and lead poisoning.

aminolevulinic acid

Oncology A drug used in photodynamic therapy which is absorbed by tumor cells and activated when exposed to light, killing the cells. See Photodynamic therapy.

aminolevulinic acid

see δ-aminolevulinic acid.
References in periodicals archive ?
Fewer than 5% have required retreatment with 20% aminolevulinic acid and photodynamic therapy (ALA-PDT).
NASDAQ NMS:DUSA) announced today that the Federal Court of Australia has ruled that the Australian patent assigned to DUSA by Queen's University which relates to DUSA's aminolevulinic acid photodynamic therapy is valid and remains in full force and effect.
Fractional carbon dioxide laser resurfacing followed by 30 minutes of aminolevulinic acid plus blue light photodynamic therapy cleared 94% of actinic keratoses, significantly more than ALA-PDT alone, according to the findings of a randomized, single-blinded, split-face study of 20 patients.
The ALAD gene codes for the enzyme [delta]-aminolevulinic acid dehydratase (ALAD), which catalyzes the second step of heme synthesis involving the condensation of two molecules of aminolevulinic acid (ALA) to form porphobilinogen.
Biochemical and immunological properties of hepatic aminolevulinic acid dehydratase in channel catfish (Ictalurus punctatus).
A single-center study of aminolevulinic acid and 417 nm photodynamic therapy in the treatment of moderate to severe acne vulgaris.
Also, on February 26, 2004, DUSA reacquired the rights to the aminolevulinic acid (Levulan) technology for Canada held by DRAXIS Health Inc.
For example, lead is known to bind to the enzyme aminolevulinic acid dehydratase (ALAD), and the absorption of lead is inversely related to calcium stores and dietary vitamin D intake (Chisolm et al.
In the scientific sessions, there were 29 lectures and presentations that were focused on, or included, Levulan(R) PDT, and/or aminolevulinic acid (ALA) PDT (ALA is the active ingredient in DUSA's Levulan).