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Related to aminolevulinic acid: porphyria
aminolevulinic acid(ALA) [ah-me″no-lev″u-lin´ik]
aminolevulinic acid/ami·no·lev·u·lin·ic ac·id/ (ALA) (-lev″u-lin´ik) δ-aminolevulinic acid; an intermediate in the synthesis of heme; blood and urinary levels are increased in lead poisoning, and urinary levels are increased in some porphyrias. The hydrochloride salt is used as a topical photosensitizer in the treatment of nonhyperkeratotic actinic keratoses.
a photochemotherapeutic agent.
indication It is used to treat nonhyperkeratotic actinic keratosis of the face and scalp.
contraindication Known hypersensitivity to porphyrins contraindicates this drug's use.
adverse effects Side effects include crusts, hypopigmentation or hyperpigmentation, ulceration, pain, itching, bleeding, and pustules at the site of application.
aminolevulinic acid (ALA)
the aliphatic precursor of heme. It is formed in the body from the condensation of glycine and succinyl coenzyme A and undergoes further condensation to form porphobilinogen. Aminolevulinic acid may be detected in the urine of some patients with porphyria, liver disease, and lead poisoning.
aminolevulinic acidOncology A drug used in photodynamic therapy which is absorbed by tumor cells and activated when exposed to light, killing the cells. See Photodynamic therapy.
see δ-aminolevulinic acid.