Photodynamic therapy with 5-aminolevulinic acid (ALA) or methyl aminolevulinate
(MAL) has very good clearance rates of 93% even with single cycle, comparable to curettage, cryotherapy and 5-FU.
Typically, after a patient applies a chemical sunscreen to block unwanted components of ultraviolet exposure, he or she applies methyl aminolevulinate
Is the pain of topical photodynamic therapy with methyl aminolevulinate
any different from that with 5-aminolaevulinic acid?
Nonenzymatic antioxidants  Low molecular Enzymes oxidants weight [16, 29, 41-44] antioxidants Antioxidant elements CAT GPx GR Uric acid SOD Vitamin C Paraoxonase Vitamin D Arylesterase Vitamin E Ions: Cu, Fe, Zn, Mn GSTs Glutathione NQO1 Coenzyme Q Peroxiredoxin-3 B-Carotene Thioredoxin-2, 6 AU FeOx [delta]-ALA-D CAT: catalase, GPx: glutathione peroxidase, GR: glutathione reductase, SOD: superoxide dismutase, GSTs: glutathione-S-transferases, NQO1: NAD(P)H:quinone oxidoreductase 1, FeOx: ferroxidase, [delta]-ALA-[delta]: 8 aminolevulinate
dehydratase, and AU: uric acid.
fluorescence cystoscopy: new diagnostic tool for photodiagnosis of superficial bladder cancer-a multicenter study.
Methyl 5- aminolevulinate
was used as the photosensitiser and only two treatments were given, one week apart.
Gilaberte27 described 5 patients with CDNH who were successfully treated with methyl aminolevulinate
photodynamic therapy (PDT).
5-Aminolevulinic acid (ALA) and its derivative methyl aminolevulinate
(ME-ALA) are the photosensitizing precursor agents most widely used in clinical practice.
Efficacy of photody-namic therapy with methyl aminolevulinate
in the treatment of superficial and nodular basal cell carcinoma: an open-label trial.
The only Food and Drug Admmistration-approved dermatologic indication for the two topical PDT photosensitizing agents--aminolevulinic acid (Levulan) and methyl aminolevulinate
(Metvixia)--is treatment of actinic keratoses.
Association between aminolevulinate
dehydrase genotypes and blood lead levels in children from a lead-contaminated area in Antofagasta, Chile.
Rhodes LE, de Rie M, Enstrom Y et al: Photodynamic therapy using topical methyl aminolevulinate