Gentamicin is a well-established aminoglycoside antibiotic
for the treatment of infection caused by gram-negative organisms.
Kanamycin is an aminoglycoside antibiotic
isolated from the soil bacterium Streptomyces kanamyceticus.
Like cisplatin, the aminoglycoside antibiotic
gentamicin causes nephrotoxicity, ototoxicity, and magnesium deficiency secondary to renal magnesium wasting.
Due to the chronic nature of these infections, pulmonary symptoms frequently require prolonged aminoglycoside antibiotic
therapy (Gibson, Burns, & Ramsey, 2003).
It is an orally-administered, encochleated formulation of the broad spectrum aminoglycoside antibiotic
agent, amikacin, which is likely to be utilised to treat different types of multidrug-resistant bacteria, including NTM and various multidrug-resistant gram negative bacterial infections.
The team led by Professor Timor Baasov of the Technion Faculty of Chemistry have modified existing aminoglycoside antibiotic
drugs, and carefully monitored biological and toxicity tests of the resulting derivatives.
Directed at new researchers without the benefit of a couple of decades of work in the field, this explains the initial work of Selman Waksman to produce streptomycin, then proceeds to such topics as the biochemistry and genetics of aminoglycoside producers, mechanics of aminoglycoside antibiotic
resistance, the development and action of kanamycin and neomycin class antibiotics, NMR structural studies and RNA interaction, structural comparisons between prokaryotic and eukaryotic ribosomal decoding, binding of antibiotics to the aminoacyl-tRNA site of bacterial ribosome, the chemistry and biological relevance of metalloaminoglycosides, adverse effects of aminoglycoside therapy, new efforts at targeting HIV-1 RNA, and novel targets for aminoglycosides.
Contract awarded for drug acquisition h2 antagonists, antipsychotic, aminoglycoside antibiotic
, bacteriostatic analgesics for hosptital san benito peten.
Plazomicin is a novel aminoglycoside antibiotic
designed to treat serious gram-negative infections.