aminocaproic acid


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aminocaproic acid

Amicar

Pharmacologic class: Carboxylic acid derivative

Therapeutic class: Antihemorrhagic, antifibrinolytic

Pregnancy risk category C

Action

Interferes with plasminogen activator substances and blocks action of fibrinolysin (plasmin)

Availability

Injection: 250 mg/ml

Syrup: 250 mg/ml

Tablets: 500 mg, 1,000 mg

Indications and dosages

Excessive bleeding caused by fibrinolysis

Adults: 5 g P.O. during first hour; then 1 to 1.25 g/hour until drug blood level of 0.13 mg/ml is reached and sustained and bleeding is controlled. Or 4 to 5 g in 250 ml of compatible diluent I.V. over 1 hour, followed by continuous infusion of 1 g/hour in 50 ml of diluent. Continue for 8 hours or until bleeding stops. Maximum daily dosage is 30 g.

Off-label uses

• Dental extractions

• Hemorrhage

Contraindications

• Hypersensitivity to drug

• Disseminated intravascular coagulation

• Neonates (injectable form)

Precautions

Use cautiously in:

• heart, hepatic, or renal failure

• upper urinary tract bleeding.

Administration

• Dilute I.V. form in normal saline solution, dextrose 5% in water, or Ringer's solution for injection. Give at prescribed rate.

• Know that oral and I.V. doses are the

Adverse reactions

CNS: dizziness, malaise, headache, delirium, hallucinations, weakness, seizures

CV: hypotension, ischemia, thrombophlebitis, cardiomyopathy, bradycardia, arrhythmias

EENT: conjunctival suffusion, tinnitus, nasal congestion

GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia

GU: intrarenal obstruction, renal failure

Hematologic: bleeding tendency, generalized thrombosis, agranulocytosis, leukopenia, thrombocytopenia

Musculoskeletal: myopathy, rhabdomyolysis

Respiratory: dyspnea, pulmonary embolism

Skin: rash, pruritus

Interactions

Drug-drug. Estrogens, hormonal contraceptives: increased risk of hypercoagulation

Activated prothrombin, prothrombin complex concentrates: increased signs of active intravascular clotting

Drug-diagnostic tests. Alanine aminotransferase, aldolase, aspartate aminotransferase, blood urea nitrogen, creatinine, creatine kinase, potassium: increased levels

Drug-herbs. Alfalfa, anise, arnica, astragalus, bilberry, black currant seed oil, capsaicin, cat's claw, celery, chaparral, clove oil, dandelion, dong quai, evening primrose oil, feverfew, garlic, ginger, ginkgo, papaya extract, rhubarb, safflower oil, skullcap: increased anticoagulant effect

Coenzyme Q10, St. John's wort: reduced anticoagulant effect

Patient monitoring

• Monitor vital signs, fluid intake and output, and ECG.

Assess for signs and symptoms of thrombophlebitis and pulmonary embolism.

Monitor neurologic status, especially for signs of impending seizure.

• Monitor kidney and liver function test results, serum electrolyte levels, and CBC with white cell differential.

• Evaluate for blood dyscrasias, particularly bleeding tendencies.

Patient teaching

• Tell patient that drug may significantly affect many body systems. Assure him that he'll be monitored closely.

Instruct patient to immediately report signs and symptoms of thrombophlebitis, pulmonary embolism, or unusual bleeding.

• Tell patient he'll undergo frequent blood testing during therapy.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and herbs mentioned above.

aminocaproic acid

A drug that reduces the tendency for fibrin in the blood to be broken down. It thus aids in the clotting of blood in wounds.
References in periodicals archive ?
Topical aminocaproic acid to prevent rebleeding in cases of traumatic hyphema.
A phase III, multicenter, randomized, placebo-controlled clinical trial of topical aminocaproic acid (Caprogel) in the management of traumatic hyphema.
Aminocaproic acid was administered less often in the reoperation for bleeding group compared to the control group (20.2% versus 30.2%, P = 0.05).
Effect of epsilon aminocaproic acid on red-cell transfusion requirements in major spinal surgery.
Systemic agents, such as lysine analogues (tranexamic acid and aminocaproic acid), desmopressin and recombinant activated Factor VII are almost never used during radical cystectomy.
NSB (b) to the coated microtitration wells, (c) % Nanoparticle Mab Mab bioconjugate (a) H117 (d) Streptavidin (dH117 (e) Blank; carboxylic acid 0.0003 0.0029 0.0004 Aminocaproic acid 0.0051 0.0061 ND Glycine 0.0019 0.0056 ND Ethanolamine 0.0005 0.0042 ND Bovine serum albumin 0.0018 0.0042 ND Bovine milk casein 0.0022 0.0033 ND Skim milk powder 0.0003 0.0021 ND Mab H50 (220) 0.12 0.0046 ND Mab 5A10 (14) 0.031 0.014 ND Mab 5A10 (43) 0.16 0.0086 ND Mab 5A10 (208) 1.7 0.0068 0.12 (a) Values in parentheses indicate number of active binding sites.
The bone pieces were ground to powder in a mill and then homogenized with a Polytron homogenizer for 15 s in 1.5 volumes of a solution of, per liter, 1 g of Triton X-100, 0.3 mol of potassium chloride, 0.5 mmol of phenylmethylsulfonyl fluoride, 2.5 mmol of benzamidine, and 50 mmol of aminocaproic acid. The extract was collected by centrifugation at 10 OOOg for 20 min at 4[degrees]C and stored at -80[degrees]C until use.
Etamsylate, Aminocaproic Acid, Cyanocobalamin, Folic Acid, Potassium Chloride, Papaverine, Phospholipids, Cinnarizine, Nitroglycerine, Furosemide, Acyclovir, Diclofenac, Omeprazole, Sodium Heparin, Pancreatin, Lisinopril, Cocarboxylase, Sodium Chloride, Calcium Gluconate, Verapamil
Electronic auction: purchase of medicinal products (sodium chloride, dextrose, procaine, aminocaproic acid, sodium hydrogen carbonate, sodium chloride) (purchase from small businesses, socially-oriented non-profit organizations)
Contract awarded for 17-0661 *** aminocaproic acid 250mg / ml, solution, ampolla or vial, iv ** ficha: 10214
Request for quotations: Supply Of Drugs For Medical Use Dextrose, Aminocaproic Acid For The Needs Of The Regional Public Health Services Budget Tuberculosis Hospital, The Ministry Of Health Of The Khabarovsk Territory.