Aminoacylation | definition of aminoacylation by Medical dictionary
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aminoacylation The attachment of an amino acid to the acceptor arm of a TRANSFER RNA molecule. This is an essential step in the synthesis of a protein. The attachment is brought about by the appropriate AMINOACYL-TRNA SYNTHETASE.
a two stage process whereby amino acids are 'activated' in order to be incorporated into proteins; energy in the form of ATP is required and one of a family of 20 aminoacyl-tRNA synthetases, one specific for each amino acid, links the carboxyl group of the amino acid to either the 2′- or 3′-hydroxyl group of the ribose unit at the 3′-end of tRNA.
References in periodicals archive
coli, it has been shown that when the rate of tRNA aminoacylation
does not meet the demands of protein synthesis, the ribosome associated RelA is activated (1).
of mutant tRNAs in MELAS but not in MERRF patients.
10:00 RIBOZYME-CATALYZED AMINOACYLATION
FROM ACETYL COA
A tRNA aminoacylation
system for non-natural amino acids based on a programmable ribozyme.
Leu(UUR)] mutation causes aminoacylation
deficiency and concomitant reduced association of mRNA with ribosomes.