aminoacylation


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aminoacylation

The attachment of an amino acid to the acceptor arm of a TRANSFER RNA molecule. This is an essential step in the synthesis of a protein. The attachment is brought about by the appropriate AMINOACYL-TRNA SYNTHETASE.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Conserved domain, GGCTlike Gamma-glutamyl cyclotransferase (GGCT), the synthesis and metabolism of glutathione 65,420 Dia4p protein-ATP binding, serine- TRNA ligase activity (GO Molecular Function), seryl-tRNA aminoacylation (GO Biological Process) 67,287 Conserved protein Domain family RT_nLTR_like (retrotransposon) 51,829 Conserved protein Domain family RT_nLTR_like (retrotransposon) 73,974 Protein ZDS2; possibly involved in chromatin silencing at rDNA, cell aging, mitotic cell cycling 52,104 Regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase, mitochondrial respiratory chain complex I assembly 5,799 No description 44,243 Viral capsid protein, controls injection/incorporation of Viral DNA to host.
Among the new additions are reactions to enable pyrrolysine biosynthesis during methylamine growth, methyl-3-mercaptopropionate metabolism, and o-phosphoserine conversion to cysteine after aminoacylation. Being able to uptake the various media components (Wolfe medium [88]) in which M.
The m.3243A>G mutation has been shown to lead to reduced levels of the tRNA [sup]Leu (UUR), decrease in aminoacylation, and absence of the normal modification with 5-taurinomethyl group at the wobble base.[sup][11],[12] Mitochondrial disease caused by this mutation may result from the reduction of mtDNA-encoded proteins and oxidative phosphorylation activity in mitochondrial translation.
Cavarelli," tRNA aminoacylation by arginyl-tRNA synthetase: induced conformations during substrates binding," EMBO Journal, vol.
The new structure shows that, like a wrench in the works, halofuginone jams the gears of a molecular machine that carries out "aminoacylation," a crucial biological process that allows organisms to synthesize the proteins they need to live.
Separately, a 3-chlorotyrosinecharged tRNA containing a CUs anticodon, was prepared by a combination of chemical synthesis and enzymatic ligation, followed by aminoacylation of 3-chlorotyrosine using an aminoacyl-tRNA synthetase (Fig.
coli, it has been shown that when the rate of tRNA aminoacylation does not meet the demands of protein synthesis, the ribosome associated RelA is activated (1).
10:00 RIBOZYME-CATALYZED AMINOACYLATION FROM ACETYL COA
They also revealed a reduced association of mRNA with ribosomes, possibly attributable to the presence of a [tRNA.sup.Leu(UUR)] aminoacylation defect.
Based on experimental data, it has been proposed that the universal codon catalog was anterior to the aminoacylation systems [57].
In this regard, methionyl-tRNA synthetase, which adds methionine to both initiator and elongator tRN[A.sup.Met], has been shown to be a substrate for GCN2, at least under some conditions, and phosphorylation of methionyl-tRNA synthetase by GCN2 prevents binding of tRNA to the enzyme, reducing the aminoacylation of both initiator and elongator tRN[A.sup.Met] [44,45].