Utilizing "Omics" to Unlock Aminoacyl-tRNA Synthetase
11:30 INCORPORATION AND INTRACELLULAR MAPPING OF HIS-TAGGED p43/EMAP II WITHIN THE MULTIENZME AMINOACYL-tRNA SYNTHETASE
Cubist has significantly broadened its target pipeline for drug discovery beyond our initial aminoacyl-tRNA synthetase
targets to include other novel targets," said Francis P.
Cubist and Pfizer entered into an eighteen-month agreement in December 1995 to screen the Pfizer compound library against certain aminoacyl-tRNA synthetase
targets and to conduct secondary screens on certain of the leads.
Cubist received the milestone payment for developing and transferring technology enabling Bristol-Myers Squibb to target specific aminoacyl-tRNA synthetase
Pfizer will collaborate with Cubist to discover novel broad spectrum antibacterial agents directed toward specific aminoacyl-tRNA synthetase
targets with activity against resistant pathogens.
The enzyme that catalyzes this amino acid-RNA attachment is the aminoacyl-tRNA synthetase
In October, the Company presented an overview of the therapeutic potential of Resolaris in RMICs at the International World Muscle Congress 2015 in Brighton, UK, as well as a broader overview of the therapeutic potential of Physiocrines at the 10th Annual International Symposium on Aminoacyl-tRNA Synthetases
In these 36 reports, contributors describe their most recent research in aminoacyl-tRNA synthetases
, the point in gene expression in which the genetic code is first defined.
Antibacterial activity will be achieved through inhibition of essential aminoacyl-tRNA synthetases
11:00 Size Identification of Aminoacyl-tRNA Synthetases
HARS is part of the ancient gene family of aminoacyl-tRNA synthetases
(aaRS), which has been known for decades to function intracellularly in protein synthesis.