(1987) A conserved amino acid sequence around Arg-68 of Artemia elongation factor 1 alpha is involved in the binding of guanine nucleotides and aminoacyl
On the seventh day of hospitalization, the results of analysis of a blood sample taken on the day of admission showed that the patient had positive titers for autoantibodies against aminoacyl
tRNA synthetase (ARS), including anti-Jo-1 antibodies.
Of these, the GARS gene located on chromosome 7p produces an aminoacyl
tRNA synthetase responsible for charging the associated tRNAs and the first protein of its kind implicated in any inherited human disorder.
The most common mechanism of aminoglycoside resistance arises from enzymatic modification rendering aminoglycosides unable to bind with the aminoacyl
site of 16S rRNA with a subsequent failure to inhibit protein synthesis .
Mode of action of few antibiotics against bacteria S.No Antibiotic Mechanism of Action Reference 1 Vancomycin Inhibits synthesis of peptidoglycan 18 in cell membrane 2 Cefotaxime Inhibits bacterial cell wall 19 synthesis 3 Rifampicin Inhibits bacterial RNA polymerase 20 4 Tetracycline Prevents the attachment of aminoacyl
21 rRNA to ribosomal acceptor (A) site 5 Streptomycin Prevents the initiation of protein 7 synthesis 6 Kanamycin Inhibits translocation during 7 protein synthesis
Biotransformation of 3-hydroxydibenzo--pyrone into 3,8 dihydroxydibenzo--pyrone and aminoacyl
conjugates by Aspergillus niger isolated from native shilajit.
Genes encoding lipid IVA acyltrasferase (msbB), biofilm formation, antimicrobial peptide resistance (carR), and 3 aminoacyl
lipid modification (almEFG) have been shown to contribute to polymyxin resistance in V cholerae (6-8).
Huang and Huang (2011) mention that methyl-parathion affects the elongation factor Tu (EF-Tu) involved in release of aminoacyl
tRNA to in A site of the ribosome.
Fusidic acid has a narrower spectrum of action; it stops protein synthesis by blocking aminoacyl
Synthesis of N alpha-protected aminoacyl
7-amino-4-methyl-coumarin amide by phosphorous oxychloride and preparation of specific fluorogenic substrates for papain.
Yokoyama, "A novel crystal form of pyrrolysyl-tRNA synthetase reveals the pre- and post-aminoacyl-tRNA synthesis conformational states of the adenylate and aminoacyl
moieties and an asparagine residue in the catalytic site," Acta Crystallographica D, vol.
Physiocrines are derived from aminoacyl
tRNA synthetases, which have been known for decades to function intracellularly in protein synthesis.