amino-terminal

a·mi·no-ter·mi·nal

(ă-mē'nō-ter'min-ăl),
The α-NH2 group or the aminoacyl residue containing it at one end of a peptide or protein (usually on the left as written).
Synonym(s): NH2-terminal

a·mi·no-ter·mi·nal

(ă-mē'nō-tĕr'mi-năl)
The α-NH2 group or the aminoacyl residue containing it at one end of a peptide or protein (usually at left as written).
References in periodicals archive ?
Trofinetide is a novel synthetic analog of the amino-terminal tripeptide of IGF-1 designed to treat the core symptoms of Rett syndrome by reducing neuroinflammation and supporting synaptic function.
The product is a novel synthetic analogue of the amino-terminal tripeptide of IGF-1 designed to treat the core symptoms of Rett syndrome by reducing neuroinflammation and supporting synaptic function.
The [beta]-domain is the amino-terminal half of MT and contains nine cysteinyl residues.
Results confirmed the previously described relationship between plasma amino-terminal propeptide of C-type natriuretic peptide (NT-proCNP) concentration and growth velocity.
Hyaluronic acid (HA), laminin (LN), collagen IV(C-IV) and amino-terminal pro-peptide of Type-III pro-collagen (PIII NP) are indices of the extent of liver fibrosis.
We sought to investigate whether the CHA2DS2-VASc score predicts stroke and death in Chinese patients with sick sinus syndrome (SSS) after pacemaker implantation and to evaluate whether the predictive power of the CHA2DS2-VASc score could be improved by combining it with left atrial diameter (LAD) and amino-terminal pro-brain natriuretic peptide (NT-proBNP).
Both B-type natriuretic peptide (BNP) and amino-terminal proBNP (NT-proBNP) are secreted from the heart in direct proportion to the degree of cardiac dysfunction and HF severity (1-4).
Histone modifications mostly occur in the exposed histone amino-terminal tails such as lysine acetylation (Kac), lysine methylation (Kme), and ubiquitination, as well as threonine and serine phosphorylation and arginine methylation [47].
[alpha]-Synuclein consists of 140 amino acid residues [24] organized in three structural regions: an amphipathic amino-terminal domain from 1 to 60 amino acid residues, responsible for the binding of [alpha]-synuclein to lipid vesicles [25, 26]; the NAC (non-amyloid-[beta] component) region from 61 to 95 amino acid residues, also found in amyloid plaques of patients suffering from Alzheimer's disease [27] and responsible for [alpha]-synuclein aggregation and [beta] sheets arrangement [28]; and the carboxy-terminal domain from 96 to 140 amino acid residues, which is the main target for the protein phosphorylation [29, 30] (Figure 1(a)).
The FMDV strain type O strain O/BY/CHA/2010 VP1, which was expressed as an amino-terminal fusion to the GAL4-DNA-binding domain, was used as the bait protein.
The MAPK signaling pathway comprises 4 distinct cascades, designated as extracellular signal regulated kinases 1/2 (ERK1/2), Jun amino-terminal kinases 1/2/3 (JNK1/2/3), p38-MAPK, and extracellular signal regulated kinase 5 (ERK5), according to their most downstream kinase tier.
This short amino-terminal extension is then proteolytically removed by specific enzymes called signal peptidases during translocation to yield the correctly folded proteins with the formation of proper disulfide bonds (11,29) Due to the lack of universal rule for selecting an appropriate signal peptide, extensive trial-and-error research has been undertaken to express periplasmic recombinant proteins using different signal peptides (11).