Nonidentities among amino acid sequences
of glycoprotein precursors and amino acid sequences
of nucleocapsid proteins of Ocozocoautla de Espinosa virus strain AV B1030026, Mexico, and 8 arenaviruses from South America * % Amino acid sequence
nonidentity Virus OCEV AMAV CHPV CPXV GTOV JUNV MACV SABV TCRV OCEV -- 43.
As a result, one of the most powerful approaches for gaining insight into genome sequences is based simply on amino acid sequence
comparisons between new, uncharacterized amino acid sequences
predicted from genome DNA sequences, and amino acid sequences
of known function.
If such preservation is far more frequent than paleontologists have expected, discerning the amino acid sequences
in ancient proteins "has enormous potential" for revealing evolutionary relationships among ancient creatures, he adds.
The amino acid sequence
is configured in three-dimensional space so that the [gamma]-core has certain characteristics.
Their analysis of the protein also showed that the amino acid sequence
in this region shares some important characteristics with the active agent of bee venom, which works by forming holes in membranes.
However, the table in (1) indicated the amino acid sequence
homologies between the novel and previous HEV isolates were similar to (some even lower than) the nucleotide sequence homologies.
The present invention uses a protein having the amino acid sequence
shown in SEQ ID NO: 1, 3, 26 or 27 in the Sequence Listing or a variant of said amino acid sequence
wherein one or more acids are substituted or deleted, or one or more acids are inserted or added and having the activity of transferring N-acetylgalactosamine (GalNAc) to N-acetylglucosamine serving as a substrate via a .
Guided by known vertebrate steroid receptors and the new mollusk receptor, the team then deduced a probable amino acid sequence
for the ancestral protein in both vertebrates and invertebrates.
In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence
shown in SEQ ID NO:2 or 4, or the nucleotide sequence set forth in SEQ ID NO:1 or 3, as well as variants thereof.
A substitution of cytosine for guanine, also located in VD 1, resulted in Gln instead of Glu at amino acid position 117, as found in genotype B and strain 6BC (numbering according to the ompA amino acid sequence
of the C.
The amino acid sequence
of the bevirimat target, the capsid-SP1 region of the HIV-1 Gag protein, from these viruses was determined by an approach called population sequencing which determines whether a significant proportion of virus within a patient exhibits resistance.
1 in Sequence Listing, a variant nucleic acid thereof, a protein with an amino acid sequence