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a potassium sparing diuretic, used as the hydrochloride salt, usually in combination with hydrochlorothiazide, in the treatment of edema and hypertension and the prevention and treatment of hypokalemia.
amiloride/amil·o·ride/ (ah-mil´ah-rīd) a potassium-sparing diuretic used as the hydrochloride salt in the treatment of edema and hypertension and in the prevention and treatment of hypokalemia.
amilorideNephrology A drug that blocks the Na+/H+ antiporter, used clinically as a potassium-sparing diuretic. See Diuretics, Potassium-sparing diuretic Pulmonology An aerosolized sodium channel blocker that may slow the progression of pulmonary dysfunction in cystic fibrosis. See Diuretics, Potassium-sparing diuretic.
amilorideA thiazide DIURETIC drug that acts by reducing reabsorption of sodium, and thus water, in the kidneys. A potassium-sparing diuretic used in the treatment of high blood pressure (HYPERTENSION), HEART FAILURE or other conditions in which excess fluid is retained in the body. The drug is on the WHO official list. Formulated in combination with other drugs under brand names such as Amil-Co, Burinex A, Fru-Co, Frumil, Kalten, Lasoride, Moducren, Moduret 25, Moduretic and Navispare.
diureticspowerful drugs, often termed 'water tablets', that control hypertension and peripheral oedema; action of some local anaesthetics is antagonized by concomitant use of some diuretics (see Table 1), e.g. aldosterone antagonists (e.g. spironolactone); carbonic anhydrase inhibitors, e.g. acetazolamide; loop diuretics, e.g. furosemide; osmotic diuretics, e.g. mannitol; potassium-sparing diuretics, e.g. amiloride, or in combination with other diuretics; thiazide diuretics, e.g. bendroflumethiazide
|Local anaesthetic agent Proprietary name||Principal drug interactions||Effect of interaction|
|Increased myocardial depression|
Increased risk of ventricular arrhythmias if lidocaine is given with quinpristin/dalfopristin
Increased risk of ventricular arrhythmias if lidocaine is given with any drug that prolongs the QT interval of the cardiac cycle
Plasma concentration of lidocaine increased by amprenavir, atazanavir and lopinavir
Increased myocardial depression
Increased risk of lidocaine toxicity when given with propranolol
The action of lidocaine is antagonized by the hypokalaemia caused by acetazolamide, loop diuretics or thiazide and related diuretics (i.e. a greater dose of lidocaine would be required to achieve anaesthesia)
Increased risk of ventricular arrhythmia if lidocaine is given with dolasetron
Plasma concentration of lidocaine increased when given with cimetidine; risk of lidocaine toxicity increased with cimetidine
|Beta-blockers||Increased risk of bupivacaine toxicity when given with propranolol|
Increased risk of myocardial depression if given with other antiarrhythmic agents
|Increased risk of myocardial depression if given with antiarrhythmic agents|
Increased risk of methaemoglobinaemia if given with sulphonamide antibacterial agents
|Antidepressants||Metabolism of ropivacaine is inhibited by fluvoxamine, thereby enhancing the risk of ropivacaine toxicity|
|Drug not listed in the British National Formulary|
a potassium-sparing diuretic.