amikacin


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amikacin

 [am″ĭ-ka´sin]
a semisynthetic aminoglycoside antibiotic derived from kanamycin, used as the sulfate salt in the treatment of a wide range of infections due to susceptible gram-negative organisms.

amikacin

/am·i·ka·cin/ (am″ĭ-ka´sin) a semisynthetic aminoglycoside antibiotic derived from kanamycin, used as the sulfate salt in the treatment of a wide range of infections due to aerobic gram-negative bacilli.

amikacin

Therapeutics The broadest of the broad-spectrum aminoglycosides, which is resistant to aminoglycoside-inactivating enzymes Indications Nosocomial gram-negative bacterial infections–eg, with Enterobacter spp, Klebsiella spp, Proteus spp, Pseudomonas aeruginosa, Serratia spp, E coli, possibly MAC Adverse effects Ototoxicity, nephrotox-icity

amikacin

An antibiotic drug, one of the AMINOGLYCOSIDES. The drug is on the WHO official list. A brand name is Amikin.
References in periodicals archive ?
The inhaled antibiotic, Amikacin Inhale, was being assessed for its effect on survival in patients with Gram-negative pneumonia.
Culture grew Mycobacterium abscessus which was sensitive to amikacin, linezolid and clarithromycin.
Pseudomonas Aeruginosa (n= 2): - Nalidixic acid (100%), Nitrofurantoin (100%) > Cotrimoxazole (50%), Norfloxacin (50%) and all were susceptible to Cefuroxime, Gentamicin and Amikacin.
Background: Aerosolized amikacin (AA) is a current option for the management of ventilator-associated pneumonia (VAP) caused by multidrug-resistant Gram-negative bacteria (MDR-GNB), as it is reported that AA could increase the alveolar level of the drug without increasing systemic toxicity.
Antimicrobial discs used for sensitivity testing by disc diffusion method were Imepenem 10mcg, piperacillin/ tazobactam 100/10 mcg, Ceftazidime 30mcg Cefotaxime 30mcg, Amikacin 30mcg, Gentamicin 10mcg, Levofloxacin 5mcg, Ceftroaxone 30 mcg, Cefoxitin 30mcg, Amoxycillin/ Clavulanic acid 20/10mcg.
For Gram-positive organisms ampicillin, cefoxitin, cefixime, azithromycin, ofloxacin, amikacin, clindamycin, amoxicillin + clavulanic acid, vancomycin, and linezolid were used.
The antibiotics tested for sensitivity were Gentamicin (30ug), Amikacin (30ug), Imipenem (10ug), Tazobactam (110ug), Septran (25ug), Fosfomycin (50ug), Nitrofurantoin (300ug), Tobramycin (30ug), Amoxacillin/clavulinic acid 2:1(30ug), Cefixime (30ug), Cefuroxime (30ug), Cefradine(30ug), Cefoperazone(75ug), Ceftriaxone (30ug), Cefotaxime (30ug), Ceftazidime (30ug), Ciprofloxacin (5ug), Ofloxacin (5ug), Levofloxacin (5ug) and Moxifloxacin (5ug).
After intravenous catheterization of the medial metatarsal vein and placing a tourniquet at the femoral-tibiotarsal joint of the right leg, regional limb perfusion with amikacin and flunixin meglumine was performed.
On the 12th day, meropenem was switched to Colistin (450 mg/day, iv) and amikacin (15 mg/kg/day, iv, for 10 days) due to hospital-acquired pneumonia with the result of deep tracheal aspiration culture positivity for carbapenem resistant, colistin and amikacin sensitive Acinetobacter baumannii plus Pseudomonas aeruginosa.
Antimicrobial discs of piperacillin/tazobactam (TZP; 100/10 ug/ml), amikacin (AK; 30 ug/ml), ciprofloxacin (CIP; 5 ug/ml), ceftazidime (CAZ; 30 ug/ml), meropenem (MEM; 10 ug/ml) and aztreonam (ATM; 30 ug/ml) were obtained from Oxoid.
Pseudomonas aeruginasa was highly sensitive to Ciprofloxacin, Amikacin and Sulbactum-cefoperazone.