amidopyrine


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a·mi·no·py·rine

(am'i-nō-pī'rēn),
Formerly widely used as an antipyretic and analgesic in rheumatism, neuritis, and common colds; may cause leukocytopenia; used to measure total body water.

amidopyrine

Aminopyrine. A painkilling drug once widely used as an aspirin substitute but now out of favour because of the risk of inducing a sometimes fatal drop in the number of white cells in the blood (AGRANULOCYTOSIS).
References in periodicals archive ?
Cerebral microsomal protein content was expressed as mg protein/ g brain, cytochrome [b.sub.5] and cytochrome [P.sub.450] contents were expressed as [eta]mol cytochrome/mg microsomal protein, glutathione S-transeferase activity was expressed as units/mg protein, NADPH cytochrome C-reductase activity was expressed as [eta]mol cytochrome C-reductase/mg protein/min, amidopyrine N-demethylase in brain microsomes was expressed as [micro]mol/min x kg brain sample, aniline-4-hydroxylase was expressed as [micro]mol/min/mg protein, and thiobarbituric acid reactive substances (TBARS) were expressed as [micro]mol TBARS/g tissue.
In the present study, we observed an overall significant induction in the activity of [P.sub.450s] (except hepatic amidopyrine N-demethylase and aniline 4-hydroxylase activities).
A significant inhibition of hepatic microsomal amidopyrine N-demethylase and aniline 4-hydroxylase activities observed in [gamma]-HCH intoxicated animals compared to control.