amastigote


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Leish·man-Don·o·van bod·y

(līsh'măn don'ŏ-văn),
the intracytoplasmic, nonflagellated leishmanial form of certain intracellular parasites, such as species of Leishmania or the intracellular form of Trypanosoma cruzi; originally used for Leishmania donovani parasites in infected spleen or liver cells in kala azar.
Synonym(s): amastigote, L-D body

Leish·man-Don·o·van bod·y

(lēsh'măn don'ŏ-văn bod'ē)
The intracytoplasmic, nonflagellated leishmanial form of certain intracellular parasites, such as species of Leishmania or the intracellular form of Trypanosoma cruzi.
Synonym(s): amastigote.

Leishman,

Sir William Boog, Scottish surgeon, 1865-1926.
Leishmania - a genus of digenetic, asexual, protozoan flagellates.
Leishman chrome cells - basophilic granular leukocytes (basophils) observed in the circulating blood of some persons with blackwater fever.
Leishman stain - a polychromed eosin-methylene blue stain used in the examination of blood films.
Leishman-Donovan body - the intracytoplasmic, nonflagellated leishmanial form of certain intracellular parasites. Synonym(s): amastigote; L-D body
leishmaniasis - tropical disease that is spread by sandflies.
References in periodicals archive ?
The two main phases of the life cycle of leishmania are; the promastigotes and amastigote. Leishmaniasis is endemic in developing as well as in developed countries and is found in all other continents except Australia and Antarctica.
Amphotericin B is the most potent leishmanicidal drug available commercially, acting against promastigote and amastigote forms of the parasite.
Peripheral blood antibodies towards rK39 antigen were positive, and bone marrow examination confirmed visceral leishmaniasis with the presence of typical Leishman-Donovan bodies (amastigote form) within the bone marrow histiocytes [Figure 2].
The life cycle of Leishmania includes extracellular promastigote in sandflies and amastigote stage that presents in mammals within mononuclear phagocyte cells (1, 2).
Dr Soomro said that in cutaneous leishmaniasis, the amastigote multiply in dermal macrophages near sand-fly bite typically on the exposed body surface such as forearms, limbs, checks or ears.
Miltefosine a new compound, derived from alkyl-phospholipids, has demonstrated its antileishmanial and antineoplastic efficacy.4 Miltefosine is the first and still the only oral agent that is being used against all types of leishmaniasis since its registration in 2002.4 Drug was approved in India first and has been used for the past decade in 14 countries for the treatment of leishmaniasis.2 The chemical name of miltefosine is hexadecylphosphocholine and the empirical formula is C21H46NO4P, yielding a molecular weight of 407.57 g/mol.4 Miltefosine acts primarily on Leishmania by affecting the promastigote and amastigote stages of the species.
These genes and proteins were tested for vaccine trials in experimental models of infection, including cruzipain [13, 14], trans-sialidase [15, 16], amastigote surface protein-2 [17], LYT-1 [18], and paraflagellar rod protein [19] among others.
Miltefosine is an alkyllysophospholipid analogue drug with in vitro activity against the promastigote and amastigote stages of Leishmania species.
Leishmania (Leishmania) amazonensis (IFLA/BR/67/PH8) was maintained as amastigote forms by several weekly passages in BALB/c mice, and as promastigote forms at 26[degrees]C in supplemented Schneider's medium, pH 7.0 (10% heat-inactivated fetal bovine serum (FBS), 100U/mL penicillin, and 100 [micro]g/mL streptomycin), as previously described [12].