amastigote


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Leish·man-Don·o·van bod·y

(līsh'măn don'ŏ-văn),
the intracytoplasmic, nonflagellated leishmanial form of certain intracellular parasites, such as species of Leishmania or the intracellular form of Trypanosoma cruzi; originally used for Leishmania donovani parasites in infected spleen or liver cells in kala azar.
Synonym(s): amastigote, L-D body

amastigote

/amas·ti·gote/ (ah-mas´tĭ-gōt) the nonflagellate, intracellular, morphologic stage in the development of certain hemoflagellates, resembling the typical adult form of Leishmania.

Leish·man-Don·o·van bod·y

(lēsh'măn don'ŏ-văn bod'ē)
The intracytoplasmic, nonflagellated leishmanial form of certain intracellular parasites, such as species of Leishmania or the intracellular form of Trypanosoma cruzi.
Synonym(s): amastigote.

Leishman,

Sir William Boog, Scottish surgeon, 1865-1926.
Leishmania - a genus of digenetic, asexual, protozoan flagellates.
Leishman chrome cells - basophilic granular leukocytes (basophils) observed in the circulating blood of some persons with blackwater fever.
Leishman stain - a polychromed eosin-methylene blue stain used in the examination of blood films.
Leishman-Donovan body - the intracytoplasmic, nonflagellated leishmanial form of certain intracellular parasites. Synonym(s): amastigote; L-D body
leishmaniasis - tropical disease that is spread by sandflies.

amastigote

an early stage in the life cycle of trypanosomes, found in invertebrates. The body is rounded and the flagellum is absent or represented by a short fibril. The kinetoplast is present.
References in periodicals archive ?
Miltefosine is an alkyllysophospholipid analogue drug with in vitro activity against the promastigote and amastigote stages of Leishmania species.
The amastigote culture at the 16 day was ready to use and was then heat shocked for use in the appropriate assays (Castro-Pinto et al.
Trypanosomatides occur in different morphological forms in its life cycle viz amastigote (leishmanial), promastigote (leptomonad), epimastigote (crithidial), trypomastigote (trypanosomal) and opisthomastigote (herpetomonad).
Her cytology (FNAC from lymph nodal lesion) and biopsy reports (both punch biopsy of the mucosal lesion and cervical lymph nodal biopsy) showed amastigote forms of leishmaniasis organism (Figure-3).
Intracellular amastigote screening will be employed as the most relevant for Leishmania spp and T cruzi.
These infective parasite forms are discharged in the feces of the triatomine and can invade new vertebrate cells, in which they undergo another round of differentiation into the intracellular amastigote forms.
Confirmation of diagnosis for VL in the study patients was carried out by (1) Demonstration of amastigote stage of parasite in aspirate material from lymph node, bone marrow, or spleen using direct light microscopy or (2) Positive serology using Direct Agglutination Test (DAT) at a significant titer of 1:6400 or more, combined with a negative Leishmanin Skin Test (LST).
En la actualidad, el tratamiento de primera eleccion para la leishmaniasis son los antimoniales pentavalentes, entre los que se incluyen: el estibogluconato de sodio (Pentostan[R]) y el antimoniato de meglumina (Glucantime[R]), cuyo mecanismo de accion es la inhibicion de la glucolisis y la oxidacion de los acidos grasos; inducen la disminucion de la biosintesis energetica del amastigote.
Skin samples were used for: (a) the preparation of smears, stained by Giemsa stain, and then examined for the presence of amastigote; (b) culture in BBA (Blood Base Agar, Difco) medium with antibiotics, incubated at 25[degrees]C and weekly observed during a month for amastigote of Leishmania sp.
In the present study of road-killed wild opossums (Didelphis uirginiana), we tested tissue from the heart muscles (where the amastigote form of the parasite prefers to encyst) for the presence of T.