amantadine


Also found in: Dictionary, Encyclopedia, Wikipedia.

amantadine

 [ah-man´tah-dēn]
an antiviral compound used as the hydrochloride salt to treat influenza A; also used as an antidyskinetic in the treatment of parkinsonism and drug-induced extrapyramidal reactions.

amantadine

(ə-măn′tə-dēn′)
n.
A drug, C10H17, used in its hydrochloride form as an antiviral agent and treatment for Parkinson's disease.

amantadine

An antiviral agent that prevents the release of viral nucleic acid into the host cells, which is most effective against influenza virus; in parkinsonism, amantadine increases presynaptic dopamine release, blocks dopamine reuptake into the presynaptic neurons and has anticholinergic effects.
 
Adverse effects
Nausea, vertigo, confusion, hallucinations, anxiety, restlessness, depression, irritability, peripheral oedema, orthostatic hypotension, psychotic reaction.

Amantadine™

Therapeutics An antiviral that prevents the release of viral nucleic acid into the host cells, which is most effective against influenza virus; in parkinsonism, amantadine ↑ presynaptic dopamine release, blocks dopamine reuptake into the presynaptic neurons, and has anticholinergic effects Adverse effects Nausea, vertigo, confusion, hallucinations, anxiety, restlessness, depression, irritability, peripheral edema, orthostatic hypotension, psychotic reaction

amantadine

An antiviral drug, also used to treat PARKINSON'S DISEASE. Brand names are Lysovir and Symmetrel.
References in periodicals archive ?
In this study, we detected a novel influenza virus A (H3N2) with Q136K mutation in NA and S31N mutation in M2, which demonstrated reduced susceptibility to both zanamivir and amantadine but remained susceptible to oseltamivir.
Negative studies include a retrospective cohort study of 123 medically stable subjects with severe TBI in coma for more than 1 week, 28 of whom had received 100 to 200 mg of amantadine twice daily [29].
While primary resistance to amantadine is uncommon (< 1 - 2.5%) it has been found to be present in some viral isolates from avian, including H5N1, and swine origins.
Amantadine has been used as an antiparkinsonian drug since 1969.
Investigators at the Centers for Disease Control and Prevention detected an "alarmingly high" resistance rate of 92% to amantadine and rimantadine in an analysis of 209 influenza A(H3N2) isolates from patients in 26 states from Oct.
In June, news reports stated that China's agricultural ministry has encouraged farmers to use amantadine on flu-infected poultry.
Observational studies strongly suggest that amantadine, rimantadine, and oseltamivir are all effective in reducing spread of influenza during outbreaks in nursing homes (Table).
The World Health Organisation says this year's strain is resistant to cheaper anti- viral drugs amantadine and rimantadine.
Medications should be tapered in the order of those with the highest risk-to-benefit ratio: Anticholinergics should be tapered first, followed by selegiline, amantadine, dopamine agonists, and catechol 0-methyltransferase inhibitors.
Now the appraisal committee will look at a new drug, Tamiflu, which is in the process of being licensed in Europe, and a new formulation of an older drug called amantadine.
Rimantadine and amantadine have been approved for use by adults and children who are 1 year of age and older.