Under the terms of the multi-target research agreement, Magenta will have access to Heidelberg Pharma's Amanitin toxin-linker platform technology.
Heidelberg Pharma developed the toxin Amanitin into cancer therapies using its proprietary ATAC technology and advanced the biological mode of action of the toxin as a novel therapeutic principle.
Under the terms of the exclusive multi-target research agreement, Heidelberg Pharma will produce Antibody Targeted Amanitin
Conjugates (ATACs) using antibodies from Takedas proprietary portfolio for up to three undisclosed targets.
Administration of cimetidine, a cytochrome P-450 inhibitor which inhibits the uptake of amatoxins by the mixed function oxidase system, and N-acetylcysteine (NAC), a glutathione precursor that binds amatoxin-related free radicals, have also been used in the treatment of amanitin intoxication.
Molecular characterization and inhibition of amanitin uptake into human hepatocytes.
While detection of amanitins is important in the diagnosis, there is no correlation between plasma concentration and clinical outcome.
The goal of the alliance is to discover and develop novel Antibody Targeted Amanitin
Conjugates (ATACs) based on the technology of Heidelberg Pharma to couple ?
Previous studies have shown that mycophagous species of Drosophila can develop on medium containing amanitin
concentrations at least an order of magnitude greater than the maximum doses that nonmycophagous species can tolerate (Jaenike et al.
Antibody Targeted Amanitin
Conjugates (ATACs), principles for maximising the drug delivery efficiency and therapeutic index and using fragment conjugates in order to develop a tailored therapy for solid tumours.
This book contains a section on amanitin
, the major toxin for this class of mushroom.
Silymarine (from the milk thistle Silibum marianum) exerts its protective effect after intravenous administration in various ways: (a) by interrupting the enterohepatic recirculation of amanitin; (b) by inhibiting the binding of toxins to hepatocyte membranes; (c) by competing with amatoxin for transmembrane transport; and (d) by inhibiting the penetration of amanitin into liver cells (1).
Methods for chromatographic determination of amanitins and related toxins in biological samples.