Emerging evidence suggests that full maturation of the alveolus occurs during the alveolarization
stage (PND 0-14) (Herriges and Morrisey 2014).
In most mammals with short gestation periods, such as rodents and lagomorphs, the birth occurs before the formation and maturaration of the alveoli in the lungs, so, in these species the alveolarization
can be considered late and/or an postnatal event (PINKERTON & JOAD, 2000).
2]S-generating enzymes cystathionine ft-synthase and cystathionine [gamma]-lyase play a role in vascular development during normal lung alveolarization
," American Journal of Physiology--Lung Cellular and Molecular Physiology, vol.
in retinoic acid receptor b deficient mice.
The researchers found that the intratracheal, rather than the intraperitoneal transplantation of human UCB-derived MSCs, significantly attenuated the hyperoxia-induced lung injury, such as decreased alveolarization
In addition, there are signs of impaired alveolarization
, such as thickened alveolar interstitial septae, a simplified alveolar pattern, and regenerative hyperplastic type II pneumocytes (1,2) (Figure 4).
1972c), "The alveolarization
on the /n/, /t/, /d/ and /tr/ in the spanish of Paraguay", en Linguistics, vol.
In the second study, hyperoxia altered the development of neonatal rat lungs, inhibiting alveolarization
and vascularization and promoting epithelial to mesenchymal transition and hyperplasia.
was evaluated measuring mean linear intercept, alveolar surface area, and the surface-to-volume ratio.
In the present study, we show that gestational but not early postnatal exposure of mice to secondhand cigarette smoke (SS) suppresses alveolarization
, angiogenesis, and development of Clara and goblet cells without significant lung inflammation and that the SS-induced effects on alveolar architecture are irreversible.
Potential mechanisms of delayed effects include interference with highly conserved factors in developmental processes such as gene regulation, molecular signaling, and growth factors involved in branching morphogenesis and alveolarization
Potential mechanisms include interference with highly conserved factors in developmental processes such as gene regulation, molecular signaling, and growth factors involved in branching morphogenesis and alveolarization