The speculation is alveolar macrophages
deposit them there as the macrophages transport asbestos fibers through the lymphatic system after phagocytizing them in the alveoli.
Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage
Mechanical ventilation exacerbates alveolar macrophage
dysfunction in the lungs of ethanol-fed rats.
Human alveolar macrophages
were obtained from recruited healthy nonsmoking subjects (age 20-40, equally divided between males and females).
Marijuana and cocaine impair alveolar macrophage
function and cytokine production.
2000) Role of pulmonary alveolar macrophages
in defense of the lung against Pseudomonas aeruginosa.
Although acute lung inflammation (ALI) caused by CS exposure does not model all aspects of COPD pathogenesis, the two processes do share certain hallmarks, including accumulation of inflammatory cells such as alveolar macrophages
and neutrophils, and lung oxidative stress (Silva Bezerra et al.
This study revealed novel effects of cigarette smoking on alveolar macrophage
physiological functions which could contribute to lung bacterial colonization by opportunistic pathogens, such as NTHI," said the researchers.
We examined the transcription level of IL-1[beta] and IL-18 and found that IL-1[beta] mRNA in alveolar macrophages
was up-regulated at 6 hr, and this level remained at a similar level throughout the 72-hr time course (Figure 1F).
In this study, we investigated P quinquefolius' immunostimulating activity in vitro by testing the ability of alveolar macrophages
(AM) to produce tumour necrosis factor alpha (TNF) in response to different extracts of P.
mice at baseline and suggested that low levels of alveolar macrophage
costimulatory molecule expression are maintained at least in part by endogenous IL-10 activity.
Environmental exposures may cause alveolar macrophage
impairment due to the presence of dusts or crystals, such as in PAP due to silico sis.