A, C, E, Control mice showing the normal collagen fibers of types I, III, and V in alveolar interstitium
. B, D, F, BHT-treated mice exhibiting a strong green birefringence of collagens I, III, and V in alveolar interstitium
of normal areas.
In the lungs involvement of airways, blood vessels and lymphatics extends to the alveolar interstitium
causing cystic change and into pulmonary veins causing haemorrhage.
Microscopic examination of transbronchial biopsies demonstrated extensive inflammatory infiltrate involving bronchial tissue and expanding adjacent alveolar interstitium
. The infiltrate consisted of plasma cells, lymphocytes, histiocytes, neutrophils, and rare multinucleated giant cells (Figure 2, original magnification x400).