aluminium phosphide


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aluminium phosphide

A pesticide used to fumigate stored grains and rodenticide. Poisoning is more common in farming communities; it is a popular and effective agent for committing suicide in India and Iran. When ingested, it reacts with gastric HCl releasing 1 g of phosphine (10 times its lethal dose), causing death in two hours.

Clinical features
Cardiovascular—arrhythmia, myocarditis, myocardial infarction, hypotensive shock, respiratory distress; GI—epigastric pain, pancreatitis, diarrhoea, vomiting; metabolic effects/chemical pathology—metabolic acidosis, hypercalcaemia, hypomagnesaemia, convulsions, liver failure, kidney failure.
 
Pathogenesis
Vascular damage, RBC membrane damage, cytochrome oxidase inhibition with mitochondrial dysfunction, end-organ hypoxia.

Mechanism
Generates phosphine gas (PH3) in contact with water.

Mortality
High.
References in periodicals archive ?
Tenders are invited for Supply of aluminium phosphide tablets conforming to bis specification no.
Summary: It's lethal to use aluminium phosphide in residential buildings and apartments, Tadweer official warns
The appeal in the Supreme Court was brought by the manufacturers of Aluminium Phosphide Tablets, an oral pesticide.
A systematic review of aluminium phosphide poisoning.
This study investigated the effects of aluminium phosphide on the behaviour, haematology, oxidative stress biomarkers and biochemistry of African catfish (C.
Free radical scavengers and lipid peroxidation in acute aluminium phosphide poisoning.
In a release issued by media liaison unit of Punjab agriculture department, experts said farmers should put aluminium phosphide tablets in rat holes and plug them.
4 had consumed aluminium phosphide and all 4 of them died.
Abdul Alghani, 37, not only lost his infant son but the child's two-year-old brother is still fighting for his life after being exposed to aluminium phosphide.
The tablets contain aluminium phosphide - a highly-toxic substance used to kill rodents underground - which is so dangerous protective suits and breathing equipment is needed when handling it.
Ministry of Environment and Water says it is working on finding 'safer alternatives' to aluminium phosphide
In a report by the Emirates 24/7, the two unnamed Filipinos succumbed after sniffing a banned pesticide called Aluminium Phosphide that leaked from the apartment's ventilation system of their neighbor.