alternative splicing


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alternative splicing

different ways of assembling exons to produce different mature mRNAs.

al·ter·na·tive splic·ing

(awl-tĕr'nă-tiv splīs'ing)
Different ways of assembling exons to produce different mature mRNAs.

alternative splicing

process in which RNA PRIMARY TRANSCRIPTS (containing INTRONS as well as EXONS) of some genes give rise to related, but different, mature mRNAs, by differences in RNA SPLICING so that different combinations of exons assemble. This increases the coding capacity of the GENOME and results in the synthesis of a range of related PROTEINS, called isoforms. Alternative splicing is also called DIFFERENTIAL SPLICING.
References in periodicals archive ?
The discovery of alternative splicing also bluntly contradicts the precept that motivated the genome project.
Whether other proteins made by alternative splicing use the particular looping-off mechanism of the troponin system is possible but remains to be seen, says Nadal-Ginard.
In this project we will test the hypothesis that alternative splicing is a central mechanism for the amplification of molecular diversity in recognition tags and their role in synaptic specificity.
Among all of the biological complexities of VEGF, the alternative splicing and the multiple isoforms generated by this process has been discussed as a basic regulatory factor in health and disease recently
They found that alternative splicing - a process by which a single gene can give rise to multiple proteins - has dramatically changed the structure and complexity of genetic messages during vertebrate evolution.
Scientists have discovered that pluripotency--the capacity of stem cells to develop into any type of cell in the human body--is regulated by a single event in a process called alternative splicing.
In this case, alternative splicing produces the same final active protein, but the 2 zymogens are released in a cell type-dependent manner and are activated differently (16).
Through this collaboration, the companies will focus their complementary expertise in alternative splicing and leverage Isis' antisense technology to expand the potential of antisense drugs in treating disease.
Transcriptional deregulation has becoming a prevailing feature in HD and changes at single-gene level in RNA biogenesis and aberrant alternative splicing (AS) events have been associated to neuronal vulnerability.
Although scientists have identified numerous proteins and RNAs that influence alternative splicing, they haven't deciphered how cells fine-tune the process to produce specific protein versions.

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