alternative pathway


Also found in: Dictionary, Wikipedia.
Related to alternative pathway: classical pathway

alternative pathway

n. Immunology
The activation of complement by direct contact with polysaccharides located on yeast cells, bacteria, or protozoans. In contrast to the classical pathway, it is a nonspecific immune response that does not rely on antibodies or T cells.
References in periodicals archive ?
As a leader in complement alternative pathway biology, we are building upon the recently reported efficacy data from our ongoing phase 2 trial with ACH-4471 for untreated PNH, and look forward to reporting the ongoing phase 2 14-day trial of ACH-4471 for patients with C3G / IC-MPGN.
The ADC Successful and Alternative Pathway group of migrant dentists were more likely to have experienced difficulties and were less satisfied with home country systems and living conditions, compared with the Direct Recognition group (from well-developed countries).
25) A deeper understanding of the physiological and pathological relevance of alternative autophagy will be obtained from the analyses of knockout mice with targeted deletions of genes specific to this alternative pathway.
Two critical issues that can potentially exacerbate inequality in teacher preparation, teacher practice, and student learning include (a) the increase in alternative pathways to teacher certification, and (b) the increase in P-12 school choice options.
However, it does not affect the formation of C3 convertase in the alternative pathway.
Specifically, in SLE the alternative pathway is preferentially activated, its selective inhibition being beneficial--probably due to positive effects of the activation of classic and lectin pathway [17, 39].
The alternative pathway, dubbed "G-APP" (Gastroenterologist: Accountable Professionalism in Practice), "represents individualized needs, supports lifelong learning and accountability, is based on performance levels using the EPA [Entrustable Professional Activities] framework [and] provides an adaptive learning module with reinforcement for competencies achieved and direction for continued learning where gaps are uncovered," Dr.
Through an alternative pathway, we train students under the age of 26 to be operators of innovative plastic materials [processes].
Hemolytic activity in classical pathway and alternative pathway was associated with variation of the porcine genes encoding the complement components pC3 (Wimmers et al.
Rather it provides an alternative pathway for graduates of other degrees to enter nursing through a shortened programme.
HHS had offered this alternative pathway to nonprofit religious employers as part of an interim final rule published in August 2014.
MANY students receiving their GCSE results this August may be looking for an alternative pathway to staying on at school or moving to sixth form.

Full browser ?