alternate-day therapy

alternate-day therapy

treatment once every 48 hours. Depending on the drug's duration of effect, this may reduce side effects. Used most commonly with glucocorticoids.
References in periodicals archive ?
The purpose of this study was to study the 30- and 60-day efficacy of alternate-day therapy (with higher dose per person; weight immaterial between 30 and 60 kg) to daily regimen (with per kg based doses) in a selected group of patients with abdominal tuberculosis.
Patients were divided to receive alternate-day therapy [H: isoniazid (600 mg), R: rifampicin (450 mg), Z: pyrazinamide (1500 mg), E: ethambutol (1200 mg)] or daily-weight-based regimen (H, 5 mg/kg/day; R, 10 mg/kg/day; Z, 20 mg/kg/day; E, 15 mg/kg/day) nonrandomly.
High-dose alternate-day therapy produced symptoms of gastritis in significant number of cases (Table2).
An offshoot of the alternate-day therapy was the realization by the patient that the abdominal discomfort was drug related so had to be tolerated.
Abramovits sometimes considers alternate-day therapy early in the course of retinoid treatment, and he said he often gives his approval to patients who want to take 1-3 day "retinoid holidays" to allow side effects to subside.