As she flips through the book, different styles of book altering
Until recently, though, scientists have focused on altering
individual proteins in a test tube to learn more about the way the molecules work.
Because phthalates can cross the placenta, exposure to the developing fetus during critical points in development is also a concern, especially if DEHP is altering
receptor-mediated differentiation pathways.
1988), and most likely due to VMAT inhibition, may further contribute to reductions in de novo synthesis of DA by altering
the affinity of tyrosine hydroxylase (TH) for its cofactor, tetrahydrobiopterin (Cooper et al.
What I think endocrine disrupters have done is show us that they-and presumably other toxicants as well-can exert their damage by mimicking, blocking, or altering
these natural signaling pathways," says McLachlan, who heads the Center for Bioenvironmental Research at Tulane and Xavier Universities in New Orleans.
An important mechanism for altering
gene expression in response to both endogenous and exogenous signals, including toxins, is altering
nuclear transcription factor activities either directly or via specific cell-signaling pathways that regulate them.
The presentations discussed four major aspects of calcium channels that are relevant for understanding their roles in genetic and environmental neurologic disorders: the genetics and molecular biology of channel structure; interactions between calcium channels and intracellular signaling pathways; the effects of toxicants on calcium channel function, both through direct interactions with channel subunits and by altering
intracellular signaling; and the genetics, molecular biology, and physiology of inherited disorders caused by mutations in the genes encoding calcium channel subunits or from autoimmune disorders caused by the generation of antibodies against subunits of those proteins.