alprostadil


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Related to alprostadil: papaverine

alprostadil

 [al-pros´tah-dil]
name for prostaglandin E1 when used pharmaceutically as a vasodilator and platelet aggregation inhibitor; used for treatment of patent ductus arteriosus and for diagnosis and treatment of impotence.

al·pros·ta·dil

(al-pros'tă-dil),
A vasodilator used for palliative therapy to maintain patency of the ductus arteriosus in neonates with congenital heart defects temporarily.
Synonym(s): prostaglandin E1

alprostadil

(ăl-prŏs′tə-dĭl)
n.
A prostaglandin drug, C20H34O5, that acts as a vasodilator and is used in suppository or injectable form to treat erectile dysfunction.

alprostadil

Urology A formulation of PGE-1 which relaxes the corpus cavernosum, allowing engorging during erection. See Erectile dysfunction, Orgasm.

alprostadil

A PROSTAGLANDIN drug used by penile injection for the treatment of impotence. An erection lasting for two or three hours is commonly achieved, but sales of alprostadil may be adversely affected by the development of drugs such as VIAGRA. Brand names are Caverject, Muse, and Viridal Duo.

Alprostadil

A smooth muscle relaxant sometimes injected into the penis or applied to the urethral opening to treat impotence.
Mentioned in: Impotence

al·pros·ta·dil

(al-pros'tă-dil)
A vasodilator used for palliative therapy to maintain patency of the ductus arteriosus in neonates with congenital heart defects temporarily.
Synonym(s): prostaglandin E1.
References in periodicals archive ?
Vitaros incorporates alprostadil, a vasodilator that is currently marketed as an injectable product or an intra-urethral insert product for patients with erectile dysfunction.
Muse is a transurethral system for the delivery of alprostadil to the male urethra.
Alprostadil is identical to naturally occurring prostaglandin EI (PGEI).
Intravenous alprostadil, an analog of prostaglandin [E.sub.1] prevents thiamylal-fentanyl-induced bronchoconstriction in humans.
Alprostadil or Caverject (synthetic [PGE.sub.1]) is most commonly used in doses of 5-40 [micro]g.
Transdermal absorption of alprostadil (AP) from its [beta] -cyclodextrin complex and O-carboxymethyl-O-ethyl- [beta] -cyclodextrin (CME- [beta] -CD) complex was compared across hairless mouse skin.
Two formulations of the topical vasodilator alprostadil are under investigation.
Treatment of ischemic ulcers of the lower limbs with alprostadil (prostaglandin E1).
Pharmacotherapy involves locally acting vasoactive drugs such as papaverin and alprostadil (Bostandjiev and Mitra, 2004), and first-line oral therapy for ED includes phosphodiesterase type 5 (PDE-5) inhibitors such as sildenafil, vardenafil, and tadalafil, which inhibit hydrolysis of the second messenger cyclic guanosine monophosphate (cGMP), whose production is promoted by nitric oxide (NO) release within the penile smooth cells (Montorsi et al., 2006; Wespes et al., 2006).
When first line therapy fails, the patient may use intracavernous injections of alprostadil (Caverject [R] or Prostin VR [R]).
Problemas especificos como la disfuncion erectil son hoy en dia entidades estudiadas y, con el advenimiento, por ejemplo, del citrato de sildenafilo (conocido popularmente, entre otros, con el nombre comercial de viagra[R]), se ha avanzado grandemente en su tratamiento (11, 17, 26, 48, 52), siendo ademas relativamente seguro utilizado en sujetos, por ejemplo, con patologia coronaria concomitante (57); se puede recurrir tambien a otras terapias tales como el alprostadil intrauretral, los dispositivos de vacio, la cirugia vascular o los distintos tipos de implantes para el pene (48, 52, 55).