alphaviruses

alphaviruses

A group of 26 viruses transmitted by mosquitoes, eight of which can cause illness, sometimes serious. Alphavirus infections feature fever, muscle and joint pain, a rash and sometimes ENCEPHALITIS. Most cases are mild.
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We tested all specimens for WNV, Shuni virus, alphaviruses, and equine encephalitis virus and submitted samples for rabies virus testing, if suspected, to Onderstepoort Veterinary Research, Onderstepoort, South Africa, as previously described (12).
2) Similar to other alphaviruses, MAYV RNA has a stop codon at the end of nsP3 gene, and at a low frequency (5-20%), a read-through translation can occur, resulting in nsP1-4 product (Fig.
34) Alphaviruses are another group of positive-sense RNA viruses transmitted through the bite of an infected mosquito and are a member of the Togaviridae family.
Viral production in EB66 cells encompasses secreted viruses, such as measles, alphaviruses, influenza A and B strains, and intracellular viruses, such as the modified vaccinia Ankara (MVA) virus.
In a sensitivity test involving all chikungunya serotypes and various alphaviruses, flaviviruses, and one phlebovirus, the RT-RPA assay identified all virus genotypes, with the only cross-reaction occurring with O'nyong'nyong virus.
They address genome structure and replication, laboratory diagnosis and detection, interaction with the interferon system, antiviral responses in mosquitoes, animal models of alphavirus-induced inflammatory disease, clinical manifestations of arthritogenic alphaviruses, encephalitic alphaviruses, the application of alphaviruses for gene therapy, and chikungunya virus pathogenesis and the development of control strategies.
The researchers studied alphaviruses, a group of RNA viruses that cause fever, encephalitis and infectious arthritis.
The topics include the scientific and ethical importance of animal models in biodefense research, characterizing new and advancing existing animal models of Bacillus anthracis infection, alphaviruses, animal models for viral hemorrhagic fevers, and in vitro and in vivo assays for staphylococcal and streptococcal superantigens.
The beauty of alphaviruses is that they are naturally attracted to dendritic cells, cells that stimulate the production of large numbers of T cells and antibodies," says Michael A.
Researchers say human trials will start within a year or two, and that the discoveries made could lead to vaccines for diseases stemming from other so-called alphaviruses, such as various deadly strains of equine encephalitis, and the Ross River virus (which is an RNA alphavirus endemic to Australia, Papua New Guinea, and other South Pacific islands).
Since, genetic conservation of CHIK V is being maintained only between human and peridomestic mosquitoes, a high degree of sequence conservation is observed within several other group of alphaviruses, e.