Alphavirus


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Related to Alphavirus: bunyavirus, flavivirus, Hepacivirus, Rubivirus

Al·pha·vi·rus

(al'fă-vī'rŭs),
One of the genera of the family Togaviridae that was formerly classified as part of the "group A" arboviruses and includes the viruses that cause eastern equine, western equine, and Venezuelan encephalitis.

Alphavirus

/Al·pha·vi·rus/ (al´fah-vi″rus) a genus of viruses of the family Togaviridae that cause encephalitis or febrile illness with rash or arthralgia.

alphavirus

(ăl′fə-vī′rəs)
n.
Any of a genus of single-stranded RNA viruses that infect animals and cause diseases such as chikungunya and Eastern equine encephalitis.

alphavirus

[al′favī′rəs]
any of a group of very small Toga viruses consisting of a single molecule of single-stranded ribonucleic acid within a lipoprotein capsule. Many alphaviruses multiply in the cytoplasm of cells of arthropods and are transmitted to humans from mosquitoes, such as those causing equine encephalitis and Semiliki Forest virus. See also encephalitis, Toga virus.

alphavirus

A member of the group-IV Togaviridae, characterised by 70-nm virions surrounding a 40-nm isometric nucleocapsid, which contains a single-stranded linear RNA.

Pathogenic alphaviruses
Eastern, Western and Venezuela equine encephalitis viruses; Sindbis virus; Semliki Forest virus (which may be used as a vector for heterologous gene expression); Ross River; O’Nyong-Nyong virus.
 
Epidemiology
Pathogenic alphaviruses of the Western hemisphere occur primarily in the summer.
 
Clinical findings
Headache, fever, chills, nausea, vomiting, mental confusion, somnolence.
 
Lab
Lymphocytosis and increased protein in CSF.
 
Management
Supportive, intensive nursing care.
 
Sequelae
Neurologic effects (e.g., mental retardation), convulsions, paralysis in 30–70% of survivors.

alphavirus

Group A arbovirus Virology A genus of the family Togaviridae characterized by 50-60 nm virions containing a single-stranded linear RNA Pathogenic alphaviruses Eastern, western, and Venezuela equine encephalitis viruses, Sindbis virus and Semliki Forest viruses–which may be used as vectors for expressing heterologous genes, Ross River, o'nyong-nyong virus Epidemiology Pathogenic alphaviruses of the Western hemisphere occur primarily in the summer Clinical Headache, fever, chills, N&V, mental confusion, somnolence Laboratory Lymphocytosis and ↑ protein in CSF Management Supportive, intensive nursing care Sequelae Neurologic effects–eg, mental retardation, convulsions, paralysis in 30–70% of survivors

Al·pha·vi·rus

(al'fă-vī'rŭs)
One of the genera of the family Togaviridae that was formerly classified as part of the "group A" arboviruses and includes the viruses that cause eastern equine, western equine, and Venezuelan encephalitis.

Alphavirus

one of the two genera in the family Togaviridae; includes eastern, western and Venezuelan equine encephalomyelitis viruses and Getah virus. All of them replicate in arthropod vectors including mosquitoes.
References in periodicals archive ?
As for most arboviral infections, the diagnosis of alphavirus infection, such as Mayaro fever, is more efficient if performed during the acute phase of the disease, either by virus isolation or RT-PCR to detect viral RNA.
25 each) from 18 and 25 June 2014 tested positive for Alphavirus.
However, caution should be exerted if considering biologic agents as etanercept was shown to aggravate articular disease in a mouse model inoculated with Ross River virus (an alphavirus similar to CHIKV) (49).
O genero Alphavirus possui 27 membros distribuidos em seis complexos que foram isolados em todos os continentes, excetuando-se a Antartida (18).
This is the first time the structure of an alphavirus has been examined in this detail," Rossmann said.
Neuroprotective interventions targeting detrimental host immune responses protect mice from fatal alphavirus encephalitis.
18) The best example of an "old world" alphavirus is Chikungunya virus.
Es una zoonosis causada por un arbovirus, virus Mayaro, del genero Alphavirus, familia Togaviridae, endemico en bosques humedos tropicales de America del Sur.
The Togaviridae family currently consists of two genera: Alphavirus (containing 27 genera of which 11 are recognized to be pathogenic for man) and Rubivirus (containing one genus Rubella the causative agent of Rubella or German Measles that is transmitted by direct human contact, inhalation of viral infected aerosol, or congenitally).
Alphavirus expression systems -promises and problems.