alphafetoprotein


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alphafetoprotein

A protein synthesized in the fetal liver and intestine and present in fetal blood and in the uterine fluid. Raised levels may indicate that the fetus has SPINA BIFIDA or ANENCEPHALY and further investigation becomes urgent. Alphafetoprotein is also produced by certain malignant tumours and its estimation is sometimes used as a marker for the diagnosis of these tumours or their recurrence.
References in periodicals archive ?
Wako Diagnostics, a division of Wako Chemicals USA, received 510(k) clearance from the FDA to market the [mu] TASWako i30 instrument with alphafetoprotein L3 (AFP-L3) and des-gamma-carboxy prothrombin (DCP) in vitro diagnostic (IVD) tests in the U.
However this observation may require clarification, since other authors report increases in serum alphafetoprotein for both hepatocellular carcinoma and cholangiocarcinoma in dogs.
Maternal serum alphafetoprotein assay using ELISA in normal pregnancy.
Seminomas with high alphafetoprotein also should be treated like a nonseminoma.
Elevated levels of serum alphafetoprotein and human chorionic gonadotropin (HCG) are clues to multiple births, and confirmation is obtained by ultrasound.
Detection of hepatocellular carcinoma with a new alphafetoprotein antibody imaging kit.
Screening for trisomy 18 has been in practice since the 1980s, when unconjugated estriol (uE3) and human chorionic gonadotropin (hCG) were added to the measurement of alphafetoprotein (AFP) as part of second trimester serum maternal screening protocols for Down syndrome.
Children with HCV should be followed every 6 to 12 months with serial LFTs to assess the degree of inflammation and measurement of serum alphafetoprotein (AFP) along with an abdominal ultrasound to screen for hepatocellular carcinoma.
One is a "triple test," in which the mother's blood is drawn during the first trimester of pregnancy and tested for levels of alphafetoprotein and two other substances that indicate the presence of Down syndrome.
Compared with no screening, using high-resolution ultrasound and serum alphafetoprotein measures every 12 months would result in an average gain of 84 quality-adjusted life days in a hypothetical population of 40-year-olds with compensated cirrhosis secondary to chronic hepatitis C infection.
Seppala, "Comparison of Amniotic Fluid and Maternal Serum AlphaFetoprotein Levels in the Early Antenatal Diagnosis of Spina Bifida and Anencephaly, The Lancet, I:429, 1974.