macroglobulin

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macroglobulin

 [mak″ro-glob´u-lin]
a protein (globulin) of high molecular weight, in the range of 1,000,000; observed in the blood in a number of diseases.
α2-macroglobulin a plasma protein that inhibits a wide variety of proteolytic enzymes, including trypsin, plasmin, thrombin, kallikrein, and chymotrypsin, by entrapping and reducing the accessibility of their functional sites to large molecules. Written also alpha2-macroglobulin.

macroglobulin

(măk′rō-glŏb′yə-lĭn)
n.
A plasma globulin of high molecular weight.

macroglobulin

Any large serum protein, usually ≥ 400 kD—e.g., IgM (900 kD), α2-macroglobulin (820 kD). Macroglobulins are detected by sharp peaks on a simple zone electrophoresis, usually in the gamma region; because of the differing charges on the radicals, the electrophoretic mobility (pI) on the agar may shift and monoclonal spikes may occur in the beta or, less commonly, in the alpha region.

macroglobulin

Any large serum protein, usually ≥ 400 kD–eg, IgM–900 kD, α2-macroglobulin–820 kD; macroglobulins are detected by sharp peaks on a simple zone electrophoresis, usually in the γ-region

macroglobulin

See IgM.
References in periodicals archive ?
Alpha2-macroglobulin as a beta-amyloid peptide-binding plasma protein.
Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation.
(36.) Chodorowska G, Wojnowska D, Juszkiewicz-Borowiec M: C-reactive protein and alpha2-macroglobulin plasma activity in medium-severe and severe psoriasis.
PSA exists in three major forms in serum: free PSA (f-PSA) and PSA complexed to the serine protease inhibitors alphal-antichymotrypsin (PSA-ACT) and alpha2-macroglobulin (PSA-AMG).
Binding of transforming growth factor-beta1 to immobilized human alpha2-macroglobulin. Arch Biochem Biophys 1992;292: 487-92.