alpha-synuclein


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alpha-synuclein

(ăl′fə-sĭ-no͞o′klē-ĭn, -nyo͞o′-)
n.
A polypeptide protein found primarily in brain neurons but seen also in the fibrils in Parkinson's disease, in the amyloid plaques of Alzheimer's disease, and in brain tissue affected by other neurodegenerative diseases.

SNCA

A gene on chromosome 4q21 that encodes alpha synuclein, which may be involved in regulating dopamine release and transport. SNCA induces fibrillisation of microtubule-associated protein tau, reduces neuronal responsiveness to apoptotic stimuli, and downregulates caspase-3.
References in periodicals archive ?
The findings suggest that it may be possible to design new therapies to replace alpha-synuclein's function or boost it in people with Parkinson's disease and other neurodegenerative disorders.
"This approach is complementary to our SLS-004 utilizing gene therapy to reduce the expression of alpha-synuclein. We have assembled a team of seasoned pharmaceutical drug developers across all key functions and provided them with ample resources to execute on our strategic plans."
The researchers then observed their motor function after treatment andA the activities of the protein alpha-synuclein, which is the primary driver of Parkinson's disease.A
Higuchi et al., "Initiation and synergistic fibrillization of tau and alpha-synuclein," Science, vol.
Schulz-Schaeffer, "The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia," Acta Neuropathology, vol.
Bouillot et al., "Binding of the PET radiotracer [[sup.18]F]BF227 does not reflect the presence of alpha-synuclein aggregates in transgenic mice," Current Alzheimer Research, vol.
Colonic inflammation, alpha-synuclein pathology in the gut, and dysbiosis of the gut microbiome in PD are among the many clues.
What the Chalmers researchers have now discovered, is that parvalbumin can form amyloid structures that bind together with the alpha-synuclein protein.
elegans Parkinson's disease (PD) model of human alpha-synuclein.
A protein called alpha-synuclein is the main component of Lewy bodies, while Alzheimer's disease (AD) is characterized by the presence of amyloid-beta plaques and tau tangles in the brain.
"Parkinson's disease is associated with abnormal processing of alpha-synuclein," explains Dr.
"We think that in rare events if it (alpha-synuclein) were to escape the appendix and enter the brain, this could lead to Parkinson's disease," Labrie told reporters.