Excess levels of either calcium or
alpha-synuclein may be what starts the chain reaction that leads to the death of brain cells.
Colonic inflammation,
alpha-synuclein pathology in the gut, and dysbiosis of the gut microbiome in PD are among the many clues.
Aprinoia Therapeutics focuses on tau,
alpha-synuclein, and novel targets for neurodegenerative diseases.
Allele-specific polymerase chain reaction was used for screening of three pathogenic single nucleotide polymorphisms in
alpha-synuclein gene.
2006) Familial Parkinson mutant
alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans.
Using the team's novel analysis techniques, the researchers at HBKU will assess the product's ability to engage with the target,
alpha-synuclein.
Lewy bodies are abnormal deposits of a protein called
alpha-synuclein.
Mice with extra
alpha-synuclein acted like they had Parkinson's: They traversed a narrow beam more slowly, they couldn't grip a pole as well and they struggled to pull stickers off their noses.
Molecular basis for preventing
alpha-synuclein aggregation by a molecular tweezer.
In fact,
alpha-synuclein aggregates are the main constituent of Lewy Bodies, characteristic proteins inclusions found in parkinsonian brains.
Mutations in
alpha-synuclein are strongly linked to development of Parkinson's disease.
alpha-Synuclein phosphorylation as a therapeutic target in Parkinson's disease.
