alpha-methylacyl-CoA racemase


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AMACR

Alpha-Methylacyl coenzyme A racemase. An enzyme involved in beta-oxidation of branched-chain fatty acids, the gene for which is overexpressed in certain cancers, in particular prostate.

alpha-methylacyl-CoA racemase

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AMACR

An antibody that is primarily used in histopathology to stain tissues suspected of representing carcinoma of the prostate gland. Its presence substantiates the diagnosis. AMACR is also present in some colonic and some kidney cancer specimens.
References in periodicals archive ?
A mouse model for alpha-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids.
Immunohistochemical stains for p63 and alpha-methylacyl-CoA racemase, versus a cocktail comprising both, in the diagnosis of prostatic carcinoma: a comparison of the immunohistochemical staining of 430 foci in radical prostatectomy and needle biopsy tissues.
Rubin, "Alpha-methylacyl-CoA racemase: a novel tumor marker over-expressed in several human cancers and their precursor lesions," American Journal of Surgical Pathology, vol.
Alpha-methylacyl-CoA racemase as a marker in the differential diagnosis of metanephric adenoma.
The oncocytoma part showed diffuse positivity for E-cadherin and weak positivity for CD117, whereas it was negative for vimentin and alpha-methylacyl-CoA racemase (AMACR).
Alpha-methylacyl-CoA racemase: a variably sensitive immunohistochemical marker for the diagnosis of small prostate cancer foci on needle biopsy.
Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma.