Diabetes mellitus, thiamine dependent megaloblastic anemia, and sensorineural deafness associated with deficient alpha-ketoglutarate dehydrogenase
A naturally occurring cofactor for the mitochondrial enzymes pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase
, LA has been shown to have a variety of properties which can interfere with the pathogenesis or progression of AD.
40) R-alpha lipoic acid is a naturally occurring cofactor for the mitochondrial enzymes pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase
It has also been shown that the AD brain has decreased activity of pyruvate dehydrogenase complex which generates acetyl-CoA, the precursor of acetylcholine from pyruvate [41, 42], decreased activity of phosphofructokinase , and alpha-ketoglutarate dehydrogenase
 but increased cerebral release of ammonia and amino acids [39, 40].