Polymorphisms that have been shown to influence the BP response to diuretics have been identified in candidate genes encoding alpha-adducin (ADD1), subunits of G-proteins (GNB3 and GNAS1), endothelial nitric oxide synthase (eNOS), and ACE (12-14).
Effects of endothelial nitric oxide synthase, alpha-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazide.
However, the knowledge on the association between the alpha-adducin gene polymorphism and blood pressure (BP) response to exercise in hypertension is limited.
The relationship between alpha-adducin polymorphism and non-dipper phenomenon in essential hypertension.
Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension.
For example, researchers monitoring patients with hypertension found that more than a third had a specific variant in a gene that encodes the structural protein alpha-adducin
. This variant leads to excess salt retention in their kidneys.