An F-actin binding protein in vertebrate cells that cross-links actin filaments into regular parallel arrays. It is found in both the Z line and the I band of striated muscle.
References in periodicals archive ?
Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB.
This complex consists of alpha-actinin and talin which bind to the cytoplasmic C-terminal tail of the integrin and paxillin and vinculin which bind to talin and alphctinin.
The effect of alpha-actinin 3 (ACTN3) and angiotensin-converting enzyme (ACE) on endurance or sprint athletic performance have been documented.
In this regard, one of the genes that may influence these phenotypes is the alpha-actinin 3 (ACTN3) gene (Clarkson et al.
1992) Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11.
2009) Human angiotensin-converting enzyme I/D and alpha-actinin 3 R577X genotypes and muscle functional and contractile properties.