An F-actin binding protein in vertebrate cells that cross-links actin filaments into regular parallel arrays. It is found in both the Z line and the I band of striated muscle.
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References in periodicals archive ?
Both Z-lines and rods contain alpha-actinin. Rods also contain thin filament proteins, such as actin, myotilin, and NEB.
Alpha-actinin is a new type of house dust mite allergen.
De Filippi et al .[28] reported that polymorphisms of the angiotensin-converting enzyme (ACE) and alpha-actinin 3 (ACTN3) could modulate the clinical symptoms of Pompe patients.
Nemaline bodies, or rods, contain Z-line material and thin filament material (alpha-actinin, actin and tropomyosin with or without desmin at the periphery).
HESC-cardiomyocytes in every group show distinct striations with alpha-actinin labeling (Figure 7).
These genes include angiotensin 1 converting enzyme 1, alpha-actinin 3 (ACTN3), myostatin, ciliary neurotrophic factor, and vitamin D receptor.
The effect of alpha-actinin 3 (ACTN3) and angiotensin-converting enzyme (ACE) on endurance or sprint athletic performance have been documented.
Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB.
In this regard, one of the genes that may influence these phenotypes is the alpha-actinin 3 (ACTN3) gene (Clarkson et al., 2005; Niemi and Majamaa, 2005; Yang et al., 2003).
(1992) Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11.
(2009) Human angiotensin-converting enzyme I/D and alpha-actinin 3 R577X genotypes and muscle functional and contractile properties.